Margaret L. Wilsher

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BACKGROUND The frequency and role of risk factors for venous thromboembolism related to air travel is uncertain. We aimed to establish the frequency of this disorder in a group of long distance air travellers and to investigate the role of potential risk factors. METHODS We designed a prospective study into which we recruited individuals aged between 18(More)
RATIONALE Clinical trial design in interstitial lung diseases (ILDs) has been hampered by lack of consensus on appropriate outcome measures for reliably assessing treatment response. In the setting of connective tissue diseases (CTDs), some measures of ILD disease activity and severity may be confounded by non-pulmonary comorbidities. METHODS The(More)
Acknowledgements The Perioperative Mortality Review Committee would like to acknowledge: the ongoing commitment to families who have lost loved ones, to learn from their deaths and develop and share solutions the organisations and workplaces that have allowed involvement of committee members the work of the staff within the Health Quality & Safety(More)
BACKGROUND We investigated the feasibility of using an online registry to provide prevalence data for multiple orphan lung diseases in Australia and New Zealand. METHODS A web-based registry, The Australasian Registry Network of Orphan Lung Diseases (ARNOLD) was developed based on the existing British Paediatric Orphan Lung Disease Registry. All adult and(More)
Hypoxic pulmonary vasoconstriction (HPV) is an adaptive response unique to the lung whereby blood flow is diverted away from areas of low alveolar oxygen to improve ventilation-perfusion matching and resultant gas exchange. Some previous experimental studies have suggested that the HPV response to hypoxia is blunted in acute pulmonary embolism (APE), while(More)
Clot load scores have previously been developed with the goal of improving prognosis in acute pulmonary embolism (PE). These scores provide a simple estimate of pulmonary vascular bed obstruction, however they have not been adopted clinically as they have poor correlation with mortality and right ventricular (RV) dysfunction. This study performed a(More)
The pulmonary circulation is a unique low resistance system that carries almost the entire cardiac output. Full or partial occlusion of pulmonary arteries by thromboemboli can result in acute elevation of right ventricular pressure, and/or hypoxaemia, but the relationship between clinical symptoms and the size or distribution of emboli is poorly described.(More)
OBJECTIVES The role vitamin D intake/production plays in sarcoidosis-associated hypercalcaemia is uncertain. However, authoritative reviews have recommended avoiding sunlight exposure and vitamin D supplements, which might lead to adverse skeletal outcomes from vitamin D insufficiency. We investigated the effects of vitamin D supplementation on surrogate(More)
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