Margaret K. Hargreaves

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Recent genome-wide association studies (GWAS) have identified multiple common genetic risk variants for breast cancer among women of Asian and European ancestry. Investigating these genetic susceptibility loci in other populations would be helpful to evaluate the generalizability of the findings and identify the causal variants for breast cancer. We(More)
To determine the prevalence and predictors of vitamin D insufficiency among black and white adult residents of the southern US. A cross-sectional analysis of serum 25(OH)D levels using baseline blood samples from 395 Southern Community Cohort Study (SCCS) participants. Participants were African-American and white adults aged 40–79 who enrolled in the study(More)
A food frequency questionnaire (FFQ) was developed to assess long-term habitual dietary intake in a cohort of approximately 100,000 40 to 79 year-old men and women living in the Southeastern US. Using the NHANES-III database for the southem region for specific race and sex subgroups, a list of 262 food categories was developed, coded and reduced to 102 food(More)
Over 73,700 adults age 40-79, nearly 70% African American, were recruited at community health centers across 12 southeastern states; individual characteristics were recorded and biologic specimens collected at baseline for later follow-up. The Southern Community Cohort Study is a unique national resource for assessing determinants of racial/ethnic(More)
OBJECTIVES We investigated whether racial disparities in the prevalence of type 2 diabetes exist beyond what may be attributable to differences in socioeconomic status (SES) and other modifiable risk factors. METHODS We analyzed data from 34331 African American and 9491 White adults aged 40 to 79 years recruited into the ongoing Southern Community Cohort(More)
OBJECTIVES To demonstrate the methods of recruitment of a low-income, predominantly African-American study population for the Southern Community Cohort Study (SCCS), a prospective epidemiologic investigation of racial disparities in cancer risk. METHODS Partnerships with community health centers (CHCs) were formed to reach underserved populations(More)
BACKGROUND Cervical cancer is largely preventable with screening using Papanicolaou (Pap) testing. We examined Pap testing among southern women, mostly of low income and educational status, to determine if rates were similar to those reported nationally and to examine which factors were related to receipt of Pap tests. METHODS Baseline interview data from(More)
In recent pooled analyses among whites and Asians, mortality was shown to rise markedly with increasing body mass index (BMI; weight (kg)/height (m)(2)), but much less is known about this association among blacks. This study prospectively examined all-cause mortality in relation to BMI among 22,014 black males, 9,343 white males, 30,810 black females, and(More)
BACKGROUND The expectation that insurance coverage mitigates health disparities and equalizes use of healthcare assumes that services are equally accessed; however, the insured low-income target population in this research had a mammography rate of 23.4%, well below the general population. Our objective was to determine the most effective intervention to(More)
OBJECTIVES African American women suffer disproportionately from many chronic diseases, and it is well acknowledged that eating patterns and habits are important contributory factors. Our goal was to describe and understand how personal and contextual factors among African American women contribute to food choices that increase the risk for chronic disease.(More)