Margaret J Leckie
Author pages are created from data sourced from our academic publisher partnerships and public sources.
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response
BACKGROUND Interleukin-5 (IL-5) is essential for the formation of eosinophils, which are thought to have a major role in the pathogenesis of asthma and other allergic diseases. We aimed to assess the… Expand
Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response
- S. A. Bryan, B. J. O'connor, S. Matti, Margaret J Leckie, P. Barnes
- The Lancet
- 23 December 2000
BACKGROUND Interleukin-12 (IL-12) is a macrophage-derived cytokine that modulates T lymphocyte responses and has the capacity to suppress allergic and eosinophilic inflammation. METHODS We carried… Expand
Measurement of granulocyte pharmacodynamics in whole blood by flow cytometry.
During the Phase I/II assessment of new therapies with the potential to suppress eosinophil and neutrophil inflammation, there is a need to assess the peripheral blood pharmacokinetic (PK) and… Expand