Margaret Hong Chen

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Cross-presentation of cell-associated antigens plays an important role in regulating CD8+ T cell responses to proteins that are not expressed by antigen-presenting cells (APCs). Dendritic cells are the principal cross-presenting APCs in vivo and much progress has been made in elucidating the pathways that allow dendritic cells to capture and process(More)
Hepatitis C virus (HCV) is a major cause of severe liver disease, and one major contributing factor is thought to involve a dysfunction of virus-specific T-cells. T-cell receptor (TCR) gene therapy with HCV-specific TCRs would increase the number of effector T-cells to promote virus clearance. We therefore took advantage of HLA-A2 transgenic mice to(More)
BACKGROUND Alphaviral replicon-based vectors induce potent immune responses both when given as viral particles (VREP) or as DNA (DREP). It has been suggested that the strong immune stimulatory effect induced by these types of vectors is mediated by induction of danger signals and activation of innate signalling pathways due to the replicase activity. To(More)
The iron L-shell ions (Fe 17+ to Fe 23+) play an important role in determining the thermal and ionization structures and line emission from photoionized plasmas. Current uncertainties in the theoretical low temperature dielectronic recombination (DR) rate coefficients for these ions significantly affect our ability to model and interpret the line emission(More)
The hepatitis C virus nonstructural (NS) 3/4A and NS5A proteins are major targets for the new direct-acting antiviral compounds. Both viral proteins have been suggested as modulators of the response to the host cell. We have shown that NS3/4A- and NS5A-specific T cell receptors confer different effector functions, and that killing of NS3/4A-expressing(More)
Hepatitis C virus (HCV) is one of the major causes of hepatocellular carcinoma (HCC) around the world. HCV promotes characteristics of cancer stem cells and the infected cells are insensitive to apoptotic signals, which lead to persistent antigen stimulation and T cell exhaustion in the host. In spite of new effective antiviral drugs, new challenges are(More)
  • Lawrence Norden, Aaron Burstein, Joseph Lorenzo Hall, Margaret Chen, Robert Kibrick, Ted Bromley +13 others
  • 2007
Law is a non-partisan public policy and law institute that focuses on fundamental issues of democracy and justice. Our work ranges from voting rights to redistricting reform, from access to the courts to presidential power in the fight against terrorism. A singular institution – part think tank, part public interest law firm, part advocacy group – the(More)
This paper develops a simulation model useful for investigating the dollar pool requirements of 20 companies who want to protect themselves from a series of large expenditures that will eventually occur. The time is uncertain. The contribution to a pool by the 20 companies is similar to an insurance arrangement. It permits a regular contribution instead of(More)
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