Margaret Duffy

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Human adenoviruses from multiple species bind to coagulation factor X (FX), yet the importance of this interaction in adenovirus dissemination is unknown. Upon contact with blood, vectors based on adenovirus serotype 5 (Ad5) binds to FX via the hexon protein with nanomolar affinity, leading to selective uptake of the complex into the liver and spleen. The(More)
It is not—unless it triggers feelings of envy. This study uses the framework of social rank theory of depression and conceptualizes Facebook envy as a possible link between Facebook surveillance use and depression among college students. Using a survey of 736 college students, we found that the effect of surveillance use of Facebook on depression is(More)
Adenoviruses are common pathogens, mostly targeting ocular, gastrointestinal and respiratory cells, but in some cases infection disseminates, presenting in severe clinical outcomes. Upon dissemination and contact with blood, coagulation factor X (FX) interacts directly with the adenovirus type 5 (Ad5) hexon. FX can act as a bridge to bind heparan sulphate(More)
Intravenous delivery of adenoviruses is the optimal route for many gene therapy applications. Once in the blood, coagulation factor X (FX) binds to the adenovirus capsid and protects the virion from natural antibody and classical complement-mediated neutralisation in mice. However, to date, no studies have examined the relevance of this FX/viral immune(More)
The treatment of edema in patients with nephrotic syndrome is generally managed by dietary sodium restriction and loop diuretics. However, edema does not improve in some patients despite adequate sodium restriction and maximal dose of diuretics. In such patients, combination of albumin and a loop diuretic may improve edema by diuresis and natriuresis. The(More)
Introduction. Congenital long QT syndrome type 2 (LQTS2) is a rare inherited cardiac abnormality resulting in increased risk of polymorphic ventricular tachycardia (PVT). Case Description. A 21-year-old postpartum female presented with syncopal episode after phone alarm. She was noted to have PVT on telemetry monitoring in the emergency department. EKG(More)
3 The undersigned, appointed by the dean of the Graduate School, have examined the dissertation entitled BUILDING A MEDIA AGENDA ON HEALTH DISPARITIES: HOW ISSUE PERCEPTIONS AND NEWS VALUES WORK TO INFLUENCE EFFECTIVENESS presented by Qi Qiu, a candidate for the degree of doctor of philosophy, and hereby certify that, in their opinion, it is worthy of(More)
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