Margaret C. May

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Specific alterations in the pulsatility of luteinizing hormone (LH) are linked to obesity-related subfertility in ovulatory women. Vervet monkeys (Chlorocebus aethiops sabaeus) are an Old World nonhuman primate that develops obesity and has a menstrual cycle similar to humans. We evaluated follicular-phase LH pulses in 12 adult normal-weight female vervets.(More)
BACKGROUND The Demand Control Model (DCM) and the Effort Reward Imbalance Model (ERI) offer putative explanations of the relationship between stressful working conditions, job strain, and psychological and physical ill health. AIMS The aims of this study are to: (a) compare the predictive powers of the two models for explaining perceived job stress and(More)
OBJECTIVE To investigate the heterogeneity of chronic fatigue syndrome (CFS/ME) in children and young people. SETTING Regional specialist CFS/ME service Patients Children and young people aged <19 years old. METHODS Exploratory factor analysis was performed on symptoms present at assessment in 333 children and young people with CFS/ME. Linear and(More)
Chronic diseases including coronary heart disease and osteoporosis represent a substantial health burden to postmenopausal women, yet the initiation of these conditions and their relationships with reproductive aging remain poorly understood. This situation is due, in part, to the lack of animal models reflecting ovarian and hormonal characteristics of(More)
Many methods of varying complexity are available for the measurement of insulin resistance (action) in man. No study has previously compared several of these in the same subjects to establish which is the most appropriate for routine use. We have, therefore, compared six methods: the hyperinsulinemic eu(iso)-glycaemic clamp (Eu), insulin glucose infusion(More)
OBJECTIVE To investigate the association of prenatal alcohol exposure with balance in10-year-old children. DESIGN Population-based prospective longitudinal study. SETTING Former Avon region of UK (Southwest England). PARTICIPANTS 6915 children from the Avon Longitudinal Study of Parents and Children who had a balance assessment at age 10 and had data(More)
The objective of the current study was to characterize luteal function in vervet monkeys. Urine from 12 adult female vervets housed at an academic research center was collected for 10 weeks from single-caged monkeys in order to assess evidence of luteal activity (ELA) as determined by urinary excretion of pregnanediol glucuronide (Pdg) and estrone(More)
Obese women exhibit decreased fertility, high miscarriage rates and dysfunctional corpus luteum (CL), but molecular mechanisms are poorly defined. We hypothesized that weight gain induces alterations in CL gene expression. RNA sequencing was used to identify changes in the CL transcriptome in the vervet monkey (Chlorocebus aethiops) during weight gain. 10(More)
OBJECTIVE The literature contains many reports of balance function in children, but these are often on atypical samples taken from hospital-based clinics and may not be generalisable to the population as a whole. The purpose of the present study is to describe balance test results from a large UK-based birth cohort study. METHODS Data from the Avon(More)