Maresuke Nakayama

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In order to get a deeper insight into comprehensive understanding of gene regulation of brain-derived neurotrophic factor (BDNF), we characterized the transcriptional apparatus of this gene on the basis of the genomic structure. The results in this study revealed that there are at least four distinctive promoters in the BDNF gene; two of them are(More)
Cystatin C, a cysteine proteinase inhibitor, is expressed in the central nervous system (CNS) as well as many other organs of mammals. However, little is known concerning whether its expression is regulated under pathological conditions of the CNS and what types of cells are responsible for this regulation. We performed differential hybridization screening(More)
In addition to the well-known erythroid 4.1 gene, two human genes (KIAA0338 and 4.1G) have recently been identified as members of the protein 4.1 family of genes. We compared the expression levels of these three genes and found that the KIAA0338 gene was predominantly expressed in human brain. To further characterize this novel protein 4.1, called brain(More)
We recently identified a gene which shows high similarity to the beta-spectrin gene but with a different chromosomal location from either of the two known beta-spectrin genes [T. Nagase, K.-I. Ishikawa, D. Nakajima, M. Ohira, N. Seki, N. Miyajima, A. Tanaka, H. Kotani, N. Nomura, O. Ohara, Prediction of the coding sequences of unidentified human genes: VII.(More)
Axonal injury and its repair are common and basic neuropathological processes in the CNS, and are composed of a complex of events in a molecular term. In order to get a comprehensive understanding of these processes, we isolated several known and unknown genes which were up-or downregulated in the facial nucleus after transection of the facial nerve by a(More)
The terminal sequences of long cDNAs from human brains were subjected to an improved method of motif-trap screening. This process resulted in the identification of three novel genes that encode proteins with 27, 27, and six cadherin domains that we denoted as KIAA1773, KIAA1774 and KIAA1775, respectively. Sequence analysis indicated that the products of(More)
Histochemical analyses of type II brain 4.1/4.1B/KIAA0987, a member of the protein 4.1 family, were carried out in rat brain. In situ hybridization (ISH) showed that type II brain 4.1 mRNA is expressed in a variety of neuronal cells. In particular, type II brain 4.1 mRNA was actively transcribed in the cells of the mesencephalon and the brainstem, which(More)
For obtaining a deeper insight into the properties of a newly characterized member of the protein 4.1 family, brain 4.1, the cellular and subcellular localization was investigated in the cerebellar cortex of adult and postnatally developing rats. Fluorescent immunohistochemical observations showed that brain 4.1 localized predominantly to glomeruli in the(More)
We report a 19-year-old man who developed a cerebral infarction in the territory of the anterior choroidal artery and showed a hypercoagulable state and nephrotic syndrome after diarrhea and appetite loss. He had suffered from nephrotic syndrome from the age of three and had been treated for five years. MR-angiography showed an occlusion originating in the(More)
Human umbilical vein endothelial cells (HUVECs) were exposed to 100-µT, 50-Hz sinusoidal intermittent (5 min off, 10 min on) magnetic fields for 24 h. Total RNA was extracted from exposed and sham-exposed cells and was then analyzed via a DNA microarray technique. Interestingly, the expression of a subunit of the L-type Ca channel was 2.3-fold higher in(More)
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