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Matrix metalloproteinases (MMPs) may play an important role in tumour cell invasion and metastasis. These processes require the dissolution of the basement membrane and the invasion of the extracellular matrix (ECM). Matrix metalloproteinase-1 (MMP-1) is a member of the collagenases, a family of MMPs that degrades collagens type II, III, the main components(More)
The breast cancer suppressor proteins BRCA1 and BRCA2 interact with RAD51, a protein essential for maintaining genomic stability by playing a central role in homology-dependent recombinational repair of the DNA double-strand breaks. Therefore, genetic variability in the RAD51 gene may contribute to the appearance and/or progression of breast cancer. A(More)
Implants used for two-stage breast reconstruction are selected exclusively on the basis of the directly measured linear parameters. Therefore, the relevant implant is not always chosen despite the wide range of available products. The aim was to analyze the clinical usefulness of three-dimensional (3D) imaging in the breast implant selection. In 50 patients(More)
INTRODUCTION The aim of the study was to evaluate the clinical usefulness of a one-step nucleic acid amplification assay (OSNA) for intraoperative detection of metastases to sentinel lymph nodes (SLNs) in comparison to examination of frozen sections, and to summarize the results of previous studies. MATERIAL AND METHODS We enrolled 98 patients aged 58.13(More)
Autologous fat transfer (AFT) is an appropriate technique for aesthetic rejuvenation of the face, aesthetic enhancement of hands, correction of the facial appearance in various disorders and constitutes a surgical alternative of treatment of numerous breast deformities ranging from distorting posttraumatic scars, post-eczema lesions, post-burn deformities(More)
OBJECTIVES To evaluate the level of oxidative damage to membrane lipids due to the breast cancer surgery in the early postoperative period. PATIENTS AND METHODS Blood samples were collected on the preoperative day and 24 hours postoperatively in 71 women operated for breast cancer, and preoperatively in 38 female patients with benign breast tumour. Lipid(More)
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