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— We present the ASKALON environment whose goal is to simplify the development and execution of workflow applications on the Grid. ASKALON is centered around a set of high-level services for transparent and effective Grid access, Grid middleware details allows the high-level composition of workflow applications. ASKALON is used to develop and port(More)
The drift towards new challenges in grid computing, including the utility grid paradigm and service level agreements based on quality-of-service guarantees, implies the need for new, robust, multi-criteria scheduling algorithms that can be applied by the user in an intuitive way. Multiple scheduling criteria addressed by the related grid research include(More)
Scheduling is a key concern for the execution of performance-driven Grid applications. In this paper we comparatively examine different existing approaches for scheduling of scientific workflow applications in a Grid environment. We evaluate three algorithms namely genetic, HEFT, and simple "myopic" and compare incremental workflow partitioning against the(More)
There is increasing evidence that depression derives from the impact of environmental pressure on genetically susceptible individuals. We analyzed the effects of chronic mild stress (CMS) on prefrontal cortex transcriptome of two strains of mice bred for high (HA)and low (LA) swim stress-induced analgesia that differ in basal transcriptomic profiles and(More)
The presentation of peptide-MHCII complexes (pMHCIIs) for surveillance by T cells is a well-known immunological concept in vertebrates, yet the conformational dynamics of antigen exchange remain elusive. By combining NMR-detected H/D exchange with Markov modelling analysis of an aggregate of 275 microseconds molecular dynamics simulations, we reveal that a(More)
The protozoan parasite Toxoplasma gondii has the ability to alter intermediate host behavior, most impressively the natural aversion to cat scent, to favor the predation by the definitive host. However, the underlying mechanism of the observed phenomenon still remains unknown. Since changes in the neurotransmitter level are postulated as a possible(More)
Most existing Grid application development environments provide the application developer with a nontransparent Grid. Commonly, application developers are explicitly involved in tedious tasks such as selecting software components deployed on specific sites, mapping applications onto the Grid, or selecting appropriate computers for their applications.(More)
The drift towards new challenges in Grid computing including scientific workflow management implies the need for new, robust, multicriteria scheduling algorithms that can be applied by the user in an intuitive way. Currently existing bi-criteria scheduling approaches for scientific workflows are usually restricted to certain criterion pairs and require the(More)