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— We present the ASKALON environment whose goal is to simplify the development and execution of workflow applications on the Grid. ASKALON is centered around a set of high-level services for transparent and effective Grid access, Grid middleware details allows the high-level composition of workflow applications. ASKALON is used to develop and port(More)
The drift towards new challenges in grid computing, including the utility grid paradigm and service level agreements based on quality-of-service guarantees, implies the need for new, robust, multi-criteria scheduling algorithms that can be applied by the user in an intuitive way. Multiple scheduling criteria addressed by the related grid research include(More)
Scheduling is a key concern for the execution of performance-driven Grid applications. In this paper we comparatively examine different existing approaches for scheduling of scientific workflow applications in a Grid environment. We evaluate three algorithms namely genetic, HEFT, and simple "myopic" and compare incremental workflow partitioning against the(More)
Most existing Grid application development environments provide the application developer with a nontransparent Grid. Commonly, application developers are explicitly involved in tedious tasks such as selecting software components deployed on specific sites, mapping applications onto the Grid, or selecting appropriate computers for their applications.(More)
There is increasing evidence that depression derives from the impact of environmental pressure on genetically susceptible individuals. We analyzed the effects of chronic mild stress (CMS) on prefrontal cortex transcriptome of two strains of mice bred for high (HA)and low (LA) swim stress-induced analgesia that differ in basal transcriptomic profiles and(More)
Toxoplasma gondii, a protozoan parasite, is capable of infecting a broad range of intermediate warm-blooded hosts including humans. The parasite undergoes sexual reproduction resulting in genetic variability only in the intestine of the definitive host (a member of the cat family). The parasite seems to be capable of altering the natural behavior of the(More)
Dissemination of primary cancer cells to distant sites is an early event in breast cancer. These cells can invade the bone marrow, rest there, and many years later disseminated tumor cells (DTC) can grow out to form overt metastases. Epithelium specific cytokeratins are commonly used as marker proteins for sensitive detection of metastatic lesions. However,(More)
It is well established that peripheral administration of interleukin-1 (IL-1) and lipopolysaccharide (LPS) can activate the hypothalamo-pituitary-adrenocortical (HPA) axis, alter brain catecholamine and indoleamine metabolism, and affect behavior. However, the mechanisms of these effects are not fully understood. Stimulation of afferents of the vagus nerve(More)