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— We present the ASKALON environment whose goal is to simplify the development and execution of workflow applications on the Grid. ASKALON is centered around a set of high-level services for transparent and effective Grid access, Grid middleware details allows the high-level composition of workflow applications. ASKALON is used to develop and port(More)
The drift towards new challenges in grid computing, including the utility grid paradigm and service level agreements based on quality-of-service guarantees, implies the need for new, robust, multi-criteria scheduling algorithms that can be applied by the user in an intuitive way. Multiple scheduling criteria addressed by the related grid research include(More)
Scheduling is a key concern for the execution of performance-driven Grid applications. In this paper we comparatively examine different existing approaches for scheduling of scientific workflow applications in a Grid environment. We evaluate three algorithms namely genetic, HEFT, and simple "myopic" and compare incremental workflow partitioning against the(More)
There is increasing evidence that depression derives from the impact of environmental pressure on genetically susceptible individuals. We analyzed the effects of chronic mild stress (CMS) on prefrontal cortex transcriptome of two strains of mice bred for high (HA)and low (LA) swim stress-induced analgesia that differ in basal transcriptomic profiles and(More)
Most existing Grid application development environments provide the application developer with a nontransparent Grid. Commonly, application developers are explicitly involved in tedious tasks such as selecting software components deployed on specific sites, mapping applications onto the Grid, or selecting appropriate computers for their applications.(More)
The drift towards new challenges in Grid computing including scientific workflow management implies the need for new, robust, multicriteria scheduling algorithms that can be applied by the user in an intuitive way. Currently existing bi-criteria scheduling approaches for scientific workflows are usually restricted to certain criterion pairs and require the(More)
It is well established that peripheral administration of interleukin-1 (IL-1) and lipopolysaccharide (LPS) can activate the hypothalamo-pituitary-adrenocortical (HPA) axis, alter brain catecholamine and indoleamine metabolism, and affect behavior. However, the mechanisms of these effects are not fully understood. Stimulation of afferents of the vagus nerve(More)
The effects of bicuculline methiodide administration into ventromedial hypothalamus (15 ng per site, bilaterally) on fear behavior and monoamines (NA, DA, 5-HT) and GABA in structures of the brain defensive system (hypothalamus, midbrain gray matter, amygdala, hippocampus and frontal cortex) were studied. Fear behavior was examined in the modified version(More)