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BACKGROUND Cell signaling via Toll-like receptors (TLRs) leads to synovial inflammation in rheumatoid arthritis (RA). We aimed to assess effects of TLR2 and TLR4 stimulation on proinflammatory cytokine production by peripheral blood mononuclear cells (PBMCs) from patients with recent-onset RA, osteoarthrosis (OA), and healthy control (HC). METHODS PBMCs(More)
BACKGROUND Stimulation of bony union by means of various physical modalities has not been widely used in clinical practice. Extracorporeal shock wave therapy (ESWT) offers the most promise. ESWT was first used to crush kidney stones (lithotripsy) in 1980. It is based on a sound rationale. Shock waves penetrate soft tissues and to release mechanical energy(More)
BACKGROUND One of the modern treatments of degenerative joint disease in young patients is hip replacement with the use of short stems. Possible advantages of stem application, in comparison to traditional procedures, include: a more physiological distribution of forces transferred through the proximal femur, prevention of stress shielding, saving more bone(More)
A massive accumulation of inflammatory cells in synovial tissues is a major pathological feature of rheumatoid arthritis (RA). Neutrophiles dominate synovial fluid while rheumatoid synovium is infiltrated with mononuclear cells. Mechanisms regulating influx of particular subpopulations of leukocytes into articular cavity and synovium compartment are not(More)
Osteoarthritis is an incurable joint disease manifesting itself with gradually progressing dege-nerative changes, leading to premature motor disability. These changes mainly occur owing to an imbalance between the processes of degeneration and regeneration of articular cartilage structures. Until now many risk factors favoring the development of(More)
Thirteen patients (19 hips) who underwent proximal femoral resection arthroplasty for symptomatic subluxation or dislocation of the hip were reviewed retrospectively. All had severe neurological involvement, and when older were non-ambulatory with spastic quadriplegia or myelodysplasia. Resections were either at the level of the neck (nine hips) or in the(More)
Background. Despite the significant progress in medicine in recent years, the number of children with cerebral palsy world-wide is growing systematically, often causing treatment problems. The goal of the present study was to evaluate lengthening of the Achilles tendon in the subcutaneous treatment of equines contractures. Material and methods. We analyzed(More)
BACKGROUND Functional bracing is a proven method of treatment of tibial fractures. Since 1998 we use individually produced braces made of "combicast" according to Schuren technique. The brace greatly limits the angulation and displacement allowing the axial compression, promoting the physiology of fracture healing. MATERIAL AND METHODS Functional bracing(More)
The aim of the study was to retrospectively review results of operative treatment for coverage deficit of femoral head in children with severe epiphysis displacement in Legg-Calvé-Perthes (LCP) disease. The material included 23 shelf acetabuloplasty procedures for LCP disease. The average age at diagnosis was 8.1 years (range 4-12). Mean follow-up was 5.8(More)