Marek Filipek

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BACKGROUND Vascular endothelial growth factor (VEGF) inhibition is a valid therapeutic approach in renal cell carcinoma. Therefore, an investigation of the combination treatment of the humanised anti-VEGF monoclonal antibody bevacizumab with interferon alfa was warranted. METHODS In a multicentre, randomised, double-blind, phase III trial, 649 patients(More)
The increase of life intensity and its stressful impact, a great number of various risk factors of ED - erectile dysfunction and aging men population lead to a high prevalence and incidence of ED worldwide. It is well known that ED in men is a condition of heterogenous aetiology, which determines ED substantial diagnostic and therapeutic clinical problem.(More)
PCNL is an up-to-date endoscopic method of nephrolithiasis treatment, characterized by high efficacy and low invasiveness. In this study we analyze our own experiences in nephrolithiasis treatment. In St. Luke Hospital, Tarnow PCNL has been the leading method of treatment of kidney stones since 1997. Low incidence of complications allows to choose this(More)
Introduction: Aging induces autonomic nervous system (ANS) dysfunction with increased sympathetic drive. Benign Prostatic Hyperplasia (BPH) is responsible for lower urinary tract symptoms (LUTS), and its pathogenesis is complex. Exemplified by previous studies, the probably cause of BPH and secondary LUTS is due to the overly active sympathetic ANS(More)
Cyclophosphamide (CYP) treatment induces chemical cystitis leading to bladder overactivity (OAB) in animals and humans. There is a great number of OAB models evaluations, which consider the bladder histology, as well as alterations in neurochemical, electrophysiological properties of bladder afferent neurons and reflex arcs activity in the spinal cord.(More)
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