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Plastic deformation in metallic glasses well below their glass transition temperatures T g occurs spatially heterogeneously within highly localized regions, termed shear transformation zones ͑STZs͒. Yet, their size and the number of atoms involved in a local shear event, remains greatly unclear. With the help of classical molecular dynamics ͑MD͒ computer(More)
Investigations of active contractions in tissue cells to date have been focused on cells that exert forces via adhesion sites to substrates or to other cells. In this study we show that also suspended epithelial cells exhibit contractility, revealing that contractions can occur independently of focal adhesions. We employ the Optical Stretcher to measure(More)
The optical stretcher, developed in our lab, is a technology to contact-free measure cellular mechanical properties with a through-put of several hundred cells per hour. Even without any biomolecular information, our approach clearly shows that the deformation of cells reflects enough information to distinguish different cell types and detect aging effects.(More)
Oscillations in the lateral pressure of lipid monolayers induced by nonlinear chemical dynamics of the second messengers MARCKS and protein kinase C Biophysical Journal, accepted, 2010
Experimental and computational dynamic force spectroscopy is widely used to determine the mechanical properties of single biomolecules. Whereas so far the focus has mainly been on rupture or unfolding forces, recent force-probe molecular dynamics simulations have revealed a strong loading rate dependence of biomolecular elasticities, which cannot be(More)
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