Mareike Röther

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Effects of the antidepressant fluoxetine in therapeutic concentration on stimulation-dependent synaptic vesicle recycling were examined in cultured rat hippocampal neurons using fluorescence microscopy. Short-term administration of fluoxetine neither inhibited exocytosis nor endocytosis of RRP vesicular membranes. On the contrary, acute application of the(More)
Electroconvulsive therapy (ECT) is effective in the treatment of treatment-resistant major depression. The fear of cognitive impairment after ECT often deters patients from choosing this treatment option. There is little reliable information regarding the effects of ECT on overall cognitive performance, while short-term memory deficits are well known but(More)
Question: A 62-year-old man with a chronic hepatitis C and liver cirrhosis Child A was referred for abdominal computed omography (CT) after a nodular liver lesion in segment V was found on ultrasonography. His medical history included esophageal arices grade I, reflux esophagitis grade III, and a posttraumatic splenectomy 50 years ago. The physical(More)
In compensatory endocytosis, scission of vesicles from the plasma membrane to the cytoplasm is a prerequisite for intravesicular reacidification and accumulation of neurotransmitter molecules. Here, we provide time-resolved measurements of the dynamics of the alkaline vesicle population which appears upon endocytic retrieval. Using fast perfusion pH-cycling(More)
Acknowledgements We thank Andreas W. Henkel for fruitful discussions and Katrin Ebert and Elke Meyer for excellent technical assistance. We would also like to thank Peter Gmeiner and Alina Tabor for assistance with the spectrophotometer. This work was conducted in partial fulfillment of the requirements for obtaining the degree Dr. rer. biol. hum. at(More)
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