Mareike Esser

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The p.P56S mutation in the VAPB gene is not due to a single founder: the first European case To the Editor: A dominant missense mutation p.P56S in the vesicle associated membrane protein associated protein B (VAPB) gene was described in eight Brazilian families of Portuguese descent showing a wide spectrum of motor neuron diseases (MNDs) including spinal(More)
Growth factors such as the neurotrophins promote neuronal survival and shape neuronal morphology. Neurotrophin receptors are located on the surface of axons and dendrites and must convey their signal retrogradely to the nucleus to influence transcription of target genes. The distance between the site of receptor activation and the nucleus is tremendous. How(More)
The multilocus Moran model with recombination is considered, which describes the evolution of the genetic composition of a population under recombination and resampling. We investigate a marginal ancestral recombination process, where each site is sampled only in one individual and we do not make any scaling assumptions in the first place. Following the(More)
We consider a fragmentation process that describes a specific way of successively removing objects from a linear arrangement. The process is a Markov chain, which is formulated in both a continuous-time and a discrete-time version. We aim at the law of the process over time. To this end, we investigate sets of realisations of this process that agree with(More)
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