Marcus Vetter

Learn More
Thoroughly designed, open-source toolkits emerge to boost progress in medical imaging. The Insight Toolkit (ITK) provides this for the algorithmic scope of medical imaging, especially for segmentation and registration. But medical imaging algorithms have to be clinically applied to be useful, which additionally requires visualization and interaction. The(More)
UNLABELLED This study investigates the effects of kyphoplasty on pain and mobility in patients with osteoporosis and painful vertebral fractures compared with conventional medical management. INTRODUCTION Pharmacological treatment of patients with primary osteoporosis does not prevent pain and impaired activity of patients with painful vertebral(More)
Renal cell carcinoma (RCC) is a constellation of malignancies of different histological subtypes arising from the renal parenchyma. The clear cell histological subtype (ccRCC) accounts for around 75% of RCCs and is characterized by distinct genetic abnormalities, of which the loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is the most(More)
Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of kidney cancer. Here, we integrated an unbiased genome-wide RNA interference screen for ccRCC survival regulators with an analysis of recurrently overexpressed genes in ccRCC to identify new therapeutic targets in this disease. One of the most potent survival regulators, the(More)
Echocardiography (cardiac ultrasound) is today the predominant technique for quantitative assessment of cardiac function and valvular heart lesions. Segmentation of cardiac structures is required to determine many important diagnostic parameters. As the heart is a moving organ, reliable information can be obtained only from three-dimensional (3-D) data over(More)
The prognosis of gliomas is generally poor since these tumors elude established therapeutic approaches. Immunotherapy might present an effective therapy in particular because the glioma cells are diffusely dispersed in the infiltration zone of the tumor and show a strong propensity to invade the surrounding brain along white matter tracts. Although various(More)
An experimental procedure was developed which allowed the simultaneous measurement of GABA in synaptosomes from 11 regions of one rat brain. Synaptosomal fractions were prepared by conventional subcellular fractionation procedures and characterized by electron microscopy. Post-mortem increases of GABA during removal and dissection of brain tissue,(More)
In medical imaging, segmentation is an important step for many visualization tasks and image-guided procedures. Except for very rare cases, automatic segmentation methods cannot guarantee to provide the correct segmentation. Therefore, for clinical usage, physicians insist on full control over the segmentation result, i.e., to verify and interactively(More)
Thein vivo effects of two GABA-elevating drugs with anticonvulsant properties, namely valproic acid (VPA) and aminooxyacetic acid (AOAA), on nerve terminal GABA levels in discrete rat brain regions were studied by means of a newly developed synaptosomal model. The profile of synaptosomal GABA increases obtained with AOAA was quite different from that seen(More)
The aim of the Medical Imaging Interaction Toolkit (MITK) is to facilitate the creation of clinically usable image-based software. Clinically usable software for image-guided procedures and image analysis require a high degree of interaction to verify and, if necessary, correct results from (semi-)automatic algorithms. MITK is a class library basing on and(More)