Marcus Thuresson

Learn More
AIMS Long-term disease progression following myocardial infarction (MI) is not well understood. We examined the risk of subsequent cardiovascular events in patients discharged after MI in Sweden. METHODS AND RESULTS This was a retrospective, cohort study linking morbidity, mortality, and medication data from Swedish national registries. Of 108 315(More)
BACKGROUND This phase II randomized, placebo-controlled study was conducted to evaluate efficacy and safety of radium-223 in patients with castration-resistant prostate cancer (CRPC) and painful bone metastases. Twelve- and 18-month survival results were reported previously. Here we report 24-month overall survival (OS) and safety data from the period 12 to(More)
OBJECTIVE The aim of this study was to investigate the associations between proton pump inhibitor (PPI) usage patterns and risk of severe gastrointestinal events in patients treated with low-dose acetylsalicylic acid (LDA). DESIGN AND SETTING A nationwide cohort study in Sweden. PATIENTS All Swedish residents ≥ 40 years of age, without cancer and(More)
Farr Institute of Health Informatics Research, University College London, London, UK; Statisticon AB, Uppsala, Sweden; Retrospective Observational Studies, Evidera, Lexington, MA, USA; Department of Pharmacology, CIC Bordeaux CIC1401 INSERM, University of Bordeaux, Bordeaux, France; Department of Mathematics, National and Kapodistrian University of Athens,(More)
Radium-223 dichloride (radium-223) mimics calcium and emits high-energy, short-range alpha-particles resulting in an antitumor effect on bone metastases. This open-label, phase IIa nonrandomized study investigated safety and short-term efficacy of radium-223 in breast cancer patients with bone-dominant disease. Twenty-three advanced breast cancer patients(More)
BACKGROUND AND OBJECTIVES Statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) are unrelated. Many patients initiated on statins experience a paradoxical decrease in HDL-C. The aim of this study was to evaluate the association between a decrease in HDL-C and risk of major adverse(More)
OBJECTIVE Peripheral artery disease (PAD) is common worldwide, and PAD patients are increasingly offered lower limb revascularization procedures. The aim of this population-based study was to describe the current risk for cardiovascular (CV) events and mortality and also to elucidate the current pharmacologic treatment patterns in revascularized lower limb(More)
This paper evaluates the OR-ULD (Overload Resolution using Utility Loss Density) algorithm for imprecise computation workloads, where tasks are decomposed into one mandatory task and one optional task. OR-ULD is a valuedriven overload resolution algorithm running in O(n log n) time, where n is the number of tasks. The algorithm is invoked only in case of(More)
BACKGROUND & AIMS Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease in pregnancy. It is associated with hepatobiliary diseases that might predispose to cancer and also with gestational diabetes and preeclampsia. In this study, we examined associations between ICP and cancer, and immune-mediated and cardiovascular diseases. (More)
OBJECTIVES New dual antiplatelet therapies (DAPTs) have been introduced in clinical practice for patients with acute coronary syndrome (ACS). This nationwide study investigated DAPT patterns over time and patient characteristics associated with the various treatments in a population with ACS. DESIGN This observational cohort study linked morbidity,(More)