Marcus T Haug

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The majority of studies attempting to evaluate the roles of hormones and neurochemicals in "aggression" concern laboratory rodents, notably rats and mice, with fewer investigations on infrahuman primates. Studies suggest that situations used to assess aggression (e.g., social conflict tests, parental attack, predatory behavior, use of unavoidable(More)
BACKGROUND Invasive aspergillosis (IA) is associated with significant morbidity and mortality in solid organ transplant recipients but data on the incidence rates stratified by type of solid organ are limited. OBJECTIVE To describe the attack rates and incidence of IA in solid organ transplant recipients, and the impact of universal Aspergillus(More)
The rat brain accumulates pregnenolone (P) as the unconjugated steroid, the sulfate ester (S) and fatty acid esters (L). P + PS do not disappear from rat brain after combined adrenalectomy (adx) and castration (orx). PL does not serve a source of P after adx + orx. P is metabolized by several rat brain regions to progesterone and to PL. Brain microsomes(More)
BACKGROUND Infectious complications continue to represent a significant source of morbidity and mortality in lung transplant recipients. Identifying specific, remediable immune defects is of potential value. After one lung transplant patient with recurrent infections was noted to be severely hypogammaglobulinemic, a screening program for humoral immune(More)
1. The impact of the serotoninergic receptor on the attack directed by female mice towards lactating intruders was assessed by studying the effects of 8-OH-DPAT (a serotoninergic agonist) and fluoxetine (an inhibitor of serotonin reuptake) on this paradigm at a range of doses and post-injection durations. 2. The specificity of these drug actions behaviour(More)
The influence of a range of drugs acting at various 5-HT receptor sites on the ultrasonic calling of mouse pups was assessed. Calling was decreased by the novel anxiolytics buspirone, ipsapirone and gepirone, and by TFMPP, spiperone, ritanserin and GR 38032F. In contrast, 8-OH-DPAT, DOI and quipazine increased the rate of calling. These effects on(More)
PURPOSE This study describes the central nervous system (CNS) events after lung transplantation. METHODS A chart review of all lung transplant recipients (LTR) to collect the clinical and neuroimaging data for CNS events defined as seizures, severe headaches, confusion, or stroke. RESULTS Twenty-six patients of 100 LTRs from 1990 through 1995 had a CNS(More)
Pregnenolone (PREG), synthesized de novo in rodent brain, is the precursor of PREG sulfate (S) and progesterone (PROG). PROG is further converted to 5 alpha-pregnane 3, 20-dione (DH PROG) and to 3 alpha-hydroxy-5 alpha-pregnan-20-one (TH PROG). PROG, DH PROG and TH PROG have been measured in the brain of male and female rats. Neither PROG nor DH PROG(More)
BACKGROUND Ganciclovir-resistant (GCV-R) cytomegalovirus (CMV) is now being reported with increasing frequency in solid organ transplant recipients. OBJECTIVE To describe the clinical characteristics and outcomes of all solid organ transplant patients with GCV-R CMV seen between 1990 and 2000 at a single center. METHODS Patients with clinically(More)
Group-housed female mice were injected IP with 0, 0.5, 1.0 or 2.0 g/kg of ethanol. Twenty min after injection, the animal's responses in a neutral cage to a docile male "standard opponent" were videotaped for 500 sec. The tapes were subsequently analysed in terms of the total times allocated by the females to non-social, social/sexual, aggressive and timid(More)