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MOTIVATION Gene expression profiling by microarrays or transcript sequencing enables observing the pathogenic function of tumors on a mesoscopic level. RESULTS We investigated neuroblastoma tumors that clinically exhibit a very heterogeneous course ranging from rapid growth with fatal outcome to spontaneous regression and detected regulatory oncogenetic(More)
This paper deals with the cutting-plane approach to the maximum stable set problem. We provide theoretical results regarding the facet-defining property of inequalities obtained by a known project-and-lift-style separation method called edge-projection, and its variants. An implementation of a Branch and Cut algorithm is described, which uses(More)
The Graphical Traveling Salesman Polyhedron (GTSP) has been proposed by Naddef and Rinaldi to be viewed as a relaxation of the Symmetric Traveling Salesman Poly-tope (STSP). It has also been employed by Applegate, Bixby, Chvátal, and Cook for solving the latter to optimality by the Branch-and-Cut method. There is a close natural connection between the two(More)
Malaria is one of the world's most common and serious diseases causing death of about 3 million people each year. Its most severe occurrence is caused by the protozoan Plasmodium falciparum. Biomedical research could enable treating the disease by effectively and specifically targeting essential enzymes of this parasite. However, the parasite has developed(More)
The reverse phase protein array (RPPA) approach was employed for a quantitative analysis of 71 cancer-relevant proteins and phosphoproteins in 84 non-small cell lung cancer (NSCLC) cell lines and by monitoring the activation state of selected receptor tyrosine kinases, PI3K/AKT and MEK/ERK1/2 signaling, cell cycle control, apoptosis, and DNA damage.(More)
Tumor therapy mainly attacks the metabolism to interfere the tumor's anabolism and signaling of proliferative second messengers. However, the metabolic demands of different cancers are very heterogeneous and depend on their origin of tissue, age, gender and other clinical parameters. We investigated tumor specific regulation in the metabolism of breast(More)