Marcus Miller

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Global metabolic profiling currently achievable by untargeted mass spectrometry-based metabolomic platforms has great potential to advance our understanding of human disease states, including potential utility in the detection of novel and known inborn errors of metabolism (IEMs). There are few studies of the technical reproducibility, data analysis(More)
This paper investigates Data-Preservation, a feature of Scientific Workflow Middleware (SWM) useful for supporting data provenance and "smart recomputation." We observe that in order for an SWM supporting Data Preservation to achieve decent performance, it should execute on top of copy-on-write file systems. Unfortunately, most file systems in-use at(More)
Adenylosuccinate lyase (ADSL) deficiency is a rare autosomal recessive neurometabolic disorder that presents with a broad-spectrum of neurological and physiological symptoms. The ADSL gene produces an enzyme with binary molecular roles in de novo purine synthesis and purine nucleotide recycling. The biochemical phenotype of ADSL deficiency, accumulation of(More)
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