Marcus J. Kitchen

Stuart B. Hooper7
Arjan B. te Pas4
Megan J. Wallace4
Robert A. Lewis3
7Stuart B. Hooper
4Arjan B. te Pas
4Megan J. Wallace
3Robert A. Lewis
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As neonatal resuscitation critically depends upon lung aeration at birth, knowledge of the progression of this process is required to guide ongoing care. We investigated whether expired CO2 (ECO2) levels indicate the degree of lung aeration immediately after birth in two animal models and in preterm infants. Lambs were delivered by caesarean section and(More)
Since lung diseases adversely affect airflow during breathing, they must also alter normal lung motion, which can be exploited to detect these diseases. However, standard imaging techniques such as CT and MRI imaging during breath-holds provide little or no information on lung motion and cannot detect diseases that cause subtle changes in lung structure.(More)
Neonatal resuscitation is one of the most frequently performed procedures, and it is often successful if the ventilation applied is adequate. Over the last decade, interest in seeking objectivity in evaluating the infant's condition at birth or the adequacy and effect of the interventions applied has markedly increased. Clinical parameters such as heart(More)
BACKGROUND A sustained inflation (SI) facilitates lung aeration, but the most effective pressure and duration are unknown. We investigated the effect of gestational age (GA) and airway liquid volume on the required inflation pressure and SI duration. METHODS Rabbit kittens were delivered at 27, 29, and 30 d gestation, intubated and airway liquid was(More)
UNLABELLED This study aimed to test the accuracy in volume measurements of three available respiratory function monitors (RFMs) for neonatal resuscitation and the effect of changing gas conditions. The Florian, New Life Box Neo-RSD (NLB Neo-RSD) and NICO RFM were tested on accuracy with volumes of 10 and 20 mL and on changes in volume measurements under(More)
Current recommendations suggest the use of positive end-expiratory pressures (PEEP) to assist very preterm infants to develop a functional residual capacity (FRC) and establish gas exchange at birth. However, maintaining a consistent PEEP is difficult and so the lungs are exposed to changing distending pressures after birth, which can affect respiratory(More)
Phase contrast X-ray imaging can provide significantly enhanced visibility of soft tissues over absorption contrast imaging with spatial resolution on the micron scale. These characteristics have enabled the visualisation of lungs aerating at birth in real time. We have developed techniques to measure regional lung air volume from these images to help(More)
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