Marcus Granegger

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During left ventricular support by rotary blood pumps (RBPs), the biomechanics of the aortic valve (AV) are altered, potentially leading to adverse events like commissural fusion, valve insufficiency, or thrombus formation. To avoid these events, assessment of AV opening and consequent adaptation of pump speed seem important. Additionally, this information(More)
AIM We applied independent component analysis (ICA) to cardiopulmonary resuscitation (CPR)-corrupted human multichannel emergency ECGs with the aim of reconstructing the original ECGs. MATERIALS Two ICA algorithms (EFICA and JADE) were selected. Data for ICA were acquired by simultaneously recording eight ECG channels during CPR on a porcine model. The(More)
BACKGROUND Guidelines for the management of a difficult airway recommend performing a cricothyrotomy in a "can't intubate/can't ventilate" situation. We investigated the tidal volumes delivered by controlled and spontaneous ventilation by seven commercially available cricothyrotomy sets (cuffed: Quicktrach II, Portex Cricothyroidotomy Kit, and Melker cuffed(More)
BACKGROUND Interruption of cardiopulmonary resuscitation (CPR) impairs the perfusion of the fibrillating heart, worsening the chance for successful defibrillation. Therefore ECG-analysis during ongoing chest compression could provide a considerable progress in comparison with standard analysis techniques working only during "hands-off" intervals. METHODS(More)
OBJECTIVES Continuous flow left ventricular assist devices are used in end-stage systolic heart failure. However, about one half of the patients with heart failure exhibit diastolic dysfunction with a normal ejection fraction. In the present study, the possible hemodynamic consequences of continuous flow left ventricular assist devices use for these(More)
GOAL Rotary blood pumps (RBPs) typically support the left ventricle by pumping blood from the ventricle to the aorta, partially bypassing the aortic valve (AV). Monitoring the AV opening during RBP support would provide important information about cardiac-pump interaction. However, currently this information is not continuously available. In this study, an(More)
PURPOSE Exercise capacity is usually evaluated by peak oxygen consumption (peak-VO2). However, assessment of peak-VO2 in patients with a left ventricular assist device (LVAD) might not be the best method to provide insight into their daily life activity. The aim of this study was to assess the postoperative activity of LVAD patients using actigraphy and to(More)
AIM Cardiopulmonary resuscitation (CPR) artefact removal methods provide satisfactory results when the rhythm is shockable but fail on non-shockable rhythms. We investigated the influence of the corruption level on the performance of four different two-channel methods for CPR artefact removal. MATERIALS AND METHODS 395 artefact-free ECGs and 13 pure CPR(More)
Monitoring of cardiac rhythms is of major importance in the treatment of heart failure patients with left ventricular assist devices (LVADs) implanted. A continuous surveillance of these rhythms could improve out-of-hospital care in these patients. The aim of this study was to investigate cardiac rhythms using available pump data only. Datasets (n = 141)(More)
AIM For the analysis of ECG rhythms during ongoing CPR, single- or two-channel methods have been proposed to eliminate artefacts from the CPR-corrupted ECG. To refine, test and evaluate these algorithms with a realistic data set, we introduce an animal model with which we created an extended database of human ECGs with real CPR artefacts. MATERIAL AND(More)