Marcos O . Machado

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BACKGROUND Bovine growth hormone (bGH) transgenic mice develop progressive glomerulosclerosis and exhibit abnormalities in hepatic lipid metabolism. We have previously shown that growth hormone up-regulates the low-density lipoprotein (LDL) receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) in mouse mesangial cells. However, a role of lipid(More)
A dysregulation of the negative feedback mechanism of the low-density lipoprotein receptor (LDL-r) induced by hormones and cytokines may contribute to the development of glomerular injury and specifically could underlie growth hormone (GH)-induced glomerulosclerosis. The present study investigates the role of GH in the regulation of LDL-r and HMG-CoA(More)
creased bilirubin, rheumatoid factor, immunoglobulins, triglycerides, or hemolyzed sera. Serum samples from 131 subjects were chosen by their T concentration to cover the Elecsys T assay analytical range (0.069–52 nmol/L) and also to include T at clinically relevant concentrations. Among these subjects we included 10 hypogonadal children, 32 patients with(More)
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