Marcos Fernandez

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This is the first report on the efficacy of a new controlled release system developed for rasagiline mesylate (RM) in a rotenone-induced rat model of Parkinson's disease (PD). PLGA microspheres in vitro released RM at a constant rate of 62.3 μg/day for two weeks. Intraperitoneal injection of rotenone (2 mg/kg/day) to Wistar rats produced typical PD(More)
15, 2009). Jones, R., 2005. The ecotoxicological effects of photosystem II herbicides on corals. Mar. Pollut. Bull. 51, 495–506. Jones, R.J., 2004. Testing the Photoinhibition model of coral bleaching using chemical inhibitors. Mar. Ecol. Prog. Ser. 284, 133–145. Jones, R.J., Kerswell, A., 2003. Phytotoxicity evaluation of Photosystem-II (PSII) herbicides(More)
In the present study, a reverse phase high performance liquid chromatographic method was developed and validated for the determination of rasagiline mesylate in biodegradable microspheres. Chromatographic separation was carried out on a RP-18 column using a mobile phase consisting of acetonitrile:water (5:95, v/v) adjusted at pH 3.1. Flow rate was 1.0 ml(More)
There are indications that the widespread use of organotin compounds (TBT and TPT) as antifoulings, as stabilizers in plastic and as pesticides, has severely affected several species of marine organisms. The most striking effect of TBT and TPT as hormonal disruptors is the development of male organs in females of gastropods, currently denominated imposex.(More)
Endocrine disruption in marine populations is a growing concern. One of the best documented examples is imposex, the development of male characteristics in female gastropods, including the development of a penis and/or vas deferens, by exposure to organotins, mainly tributyltin. This syndrome has been an effective and widely used biomarker of organic tin(More)
Presentation skills, such as oral expression and public speaking, have normally been relegated to the background in engineering degree programs. In recent years, however, the labor market has specifically demanded these kinds of skills in engineers. Accordingly, new engineering degrees, adapted to the goals of the Bologna Declaration or ABET criteria,(More)
The use of OTC (organotin compounds) as biocides in naval antifouling paints causes impacts on non-target organisms. One of these impacts is a syndrome called imposex in gastropod molluscs. Imposex is the imposition of male secondary sexual characteristics in female gastropods as result of endocrine disruption. In this preliminary study, imposex was(More)
Imposex, an endocrine disruption phenomenon, is a biomarker of tributyltin (TBT) exposure in marine gastropod populations. The occurrence and intensity of the syndrome in populations of the neogastropod Stramonita haemastoma were ascertained at nine sampling stations in October 2008 at Arraial do Cabo, a very important tourist resort in Rio de Janeiro state(More)
In Brazil, there is no restriction to the use of organotins (OTs). Previous investigations have shown that hepatic SigmaSn in cetaceans is predominantly organic. Hepatic SigmaSn concentrations were determined by GFAAS in 67 cetaceans (13 species) that stranded on Rio de Janeiro (RJ) and Espirito Santo (ES) states. Concentrations (in ng/g wet wt.) of marine(More)
Stramonita haemastoma was investigated as a suitable bioindicator of TBT and TPhT contamination in the tropical Atlantic Ocean by: 1. Imposex induction in healthy females after inoculation with TBT and TPhT in the laboratory; and 2. Determining incidence of imposex in S. haemastoma collected from areas with various levels of tributyltin (TBT) and(More)