Marcos Catanho

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Several databases and computational tools have been created with the aim of organizing, integrating and analyzing the wealth of information generated by large-scale sequencing projects of mycobacterial genomes and those of other organisms. However, with very few exceptions, these databases and tools do not allow for massive and/or dynamic comparison of(More)
UNLABELLED The widely used programs BLAST (in this article, 'BLAST' includes both the National Center for Biotechnology Information [NCBI] BLAST and the Washington University version WU BLAST) and FASTA for similarity searches in nucleotide and protein databases usually result in copious output. However, when large query sets are used, human inspection(More)
iniciativa pioneira do Depar-tamento de Energia Norte-Americano (DOE) de obter uma seqüência genômica humana de referência que pudesse atender melhor os seus propósitos de compreender os riscos potenciais para a saúde e para o meio ambiente decor-rentes da produção e do uso de novas fontes de energia e novas tecnologias, culminou no lançamento do Projeto(More)
Trypanosoma cruzi, the etiological agent of Chagas disease, is auxotrophic for arginine. It obtains this amino acid from the host through transporters expressed on the plasma membrane and on the membranes of intracellular compartments. A few cationic amino acid transporters have been characterized at the molecular level, such as the novel intracellular(More)
MOTIVATION Many analyses in modern biological research are based on comparisons between biological sequences, resulting in functional, evolutionary and structural inferences. When large numbers of sequences are compared, heuristics are often used resulting in a certain lack of accuracy. In order to improve and validate results of such comparisons, we have(More)
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