Marcos A L Cordeiro

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Human immunodeficiency virus type 1 (HIV-1) and other retroviruses require integration of a double-stranded DNA copy of the RNA genome into the host cell chromosome for productive infection. The viral enzyme, integrase, catalyzes the integration of retroviral DNA and represents an attractive target for developing antiretroviral agents. We identified several(More)
The main purpose of image processing and analysis is, often, to segment the image into objects in order to analyze the geometrical properties and the structure of the objects and recognize them. The analysis of the geometric objects must be quantitative, because only such an analysis and description of the geometric objects can provide a coherent(More)
Integration of a cDNA copy of the human immunodeficiency virus (HIV) genome is mediated by an HIV-1-encoded enzyme, integrase (IN), and is required for productive infection of CD4+ lymphocytes. It had been shown that 3,5-dicaffeoylquinic acid and two analogues were potent and selective inhibitors of HIV-1 IN in vitro. To determine whether the inhibition of(More)
A capillary gas chromatographic-mass spectrometric method using selected ion monitoring was developed for the analysis of cotinine in urine, serum and oral samples. The procedure requires 500 microliters of an oral sample, 250 microliters of a serum sample and 50 microliters of urine and can detect 5 ng/ml cotinine in oral samples, 10 ng/ml in serum and 50(More)
OBJECTIVES Recent advances in magnetic resonance imaging (MRI) technology has allowed the development of imaging sequences tailored to the assessment of minute anatomic detail of the temporal bone structures. Volume Rendering (VR) is a 3D rendering method used in MRI. It helps in understanding complex anatomic conditions and is particularly useful in the(More)
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