Marco Stieger

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Irritant contact dermatitis is a result of activated innate immune response to various external stimuli and consists of complex interplay which involves skin barrier disruption, cellular changes, and release of proinflammatory mediators. In this review, we will focus on key cytokines and chemokines involved in the pathogenesis of irritant contact dermatitis(More)
BACKGROUND Previously published studies concerning autopsy findings in ovarian cancer failed to consider the broad differences in factors that influence the course of disease. Furthermore, those studies were conducted when the currently accepted standards in diagnostics and therapy had not been fully established. The objective of the current study was to(More)
BACKGROUND Painful cutaneous injection site reactions may hamper treatment with interferon β (IFN-β) and glatiramer acetate (GA) in multiple sclerosis (MS) patients. OBJECTIVE To maintain therapy adherence, efficient therapeutic modalities for these subcutaneous inflammatory lesions are urgently needed. We tested the application of local extracorporeal(More)
During eating, human saliva is secreted into the oral cavity by salivary glands. The relative contribution of different glands to total salivary flow rate depends, among other factors, on the tastants in the food. Few reports indicated that also the salivary protein composition depends on the tastant make-up of the food. We studied the influence of(More)
In a period of 15 months 601 patients (440 males, 161 females) with uncomplicated genital gonorrhea were examined bacteriologically and clinically. Diagnosis was by microscopy and culture. The sensitivity of the gonococci strains to antibiotics was tested by agar disc and the agar plate dilution culture media. 10 cases of penicillinase producing gonococci(More)
Of a group of 53 anamnestically assured bee venom allergies 81.1% positive skin tests (bee whole body extract) as well as 79% positive RAST (bee venom) could be proven. A statistical connection between skin test and clinic reaction degree, as well as between "RAST-clinic reaction degree" and "skin test--RAST" could not be found. The agreement between skin(More)
A new subgroup of malignant melanoma, acral-lentiginous melanoma (ALM), is presented, which the authors have diagnosed in 8% of their melanoma patients. In a retrospective study the clinical and pathological findings in 44 patients with ALM are reviewed. A relationship was found between age, tumor diameter and thickness, pigmentation, ulceration,(More)
BACKGROUND Gorlin syndrome, also known as the basal cell nevus syndrome (OMIM #109400), is a rare autosomal-dominant genetic disease. The disease, which shows mutation of the patched receptor gene (PTCH1) of the sonic hedgehog pathway, is characterized by developing multiple basal cell carcinomas (BCCs) in adolescent patients. Other clinical features(More)