Marco Retzlaff

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Hepadnaviruses are DNA viruses that replicate by protein-primed reverse transcription, employing a specialized reverse transcriptase (RT), P protein. DNA synthesis from the pregenomic RNA is initiated by binding of P to the epsilon signal. Using epsilon as template and a Tyr-residue for initiation, the RT synthesizes a DNA oligo (priming) as primer for(More)
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