Marco R. de Groot

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The presence of circulating tumor cells (CTC) is an independent prognostic factor for progression-free survival and breast cancer-related death (BRD) for patients with metastatic breast cancer beginning a new line of systemic therapy. The current study was undertaken to explore whether the presence of CTC at the time of diagnosis was associated with(More)
BACKGROUND Presence of circulating tumor cells (CTC) in patients with metastatic breast, colorectal and prostate cancer is indicative for poor prognosis. An automated CTC (aCTC) algorithm developed previously to eliminate the variability in manual counting of CTC (mCTC) was used to extract morphological features. Here we validated the aCTC algorithm on CTC(More)
Purpose: Although unequivocal evidence has shown the prog-nostic relevance of circulating tumor cells (CTC) in the peripheral blood of patients with metastatic breast cancer, less evidence is available for the prognostic relevance of CTCs at the time of primary diagnosis. Experimental Design: We conducted a pooled analysis of individual data from 3,173(More)
AIM To evaluate the prevalence and cause of central sleep apnea (CSA) and central sleep apnea syndrome (CAS) in patients with syndromic craniosynostosis. MATERIALS AND METHODS This prospective study included ambulant sleep study data to assess, central apneas and obstructive apneas. Data on hindbrain herniation were obtained using cerebral magnetic(More)
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