Marco Pugliese

Learn More
This paper proposes a methodology for detecting network-layer anomalies in wireless sensor networks using weak process models (WPM). Weak process models are a non-parametric version of Hidden Markov models (HMM), wherein state transition probabilities are reduced to rules of reachability. Specifically, we present an intrusion detection system based on(More)
—Secure monitoring services supported by flexible, manageable, and cheap systems in areas where ordinary networks are unsuitable: this is one of today challenges in health monitoring engineering. Wireless Sensor Networks represent a promising technological solution but resource constraints and exposure to external attacks could limit their employment. The(More)
A Wireless Sensor Network (WSN) is a versatile and distributed sensing system that is able to support a wide variety of application domains. One of the most important issue in WSN design is to guarantee the reliability of the collected data which involves in turn security issues across wireless links. This paper deals with the cryptographic aspects in the(More)
BACKGROUND Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disorder of the central nervous system (CNS) and is the leading cause of nontraumatic disability among young adults. Activated microglial cells are important effectors of demyelination and neurodegeneration, by secreting cytokines and others neurotoxic agents. Previous studies have(More)
Single and double-labeling immunocytochemistry has been used to learn about the localization, distribution, and possible relationship between beta-amyloid protein (Abeta) deposition and tau hyperphosphorylation in the canine cerebral cortex with age. Behavioral impairment, as reported by the owners and tested in all dogs, correlated with increased Abeta(More)
Brain damage caused by an acute injury depends on the initial severity of the injury and the time elapsed after the injury. To determine whether these two variables activate common mechanisms, we compared the response of the rat medial septum to insult with a graded series of concentrations of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)(More)
Like humans, canines develop with aging beta-amyloid (Abeta) plaques and a progressive cognitive deficit on tasks similar to those used in diagnosis and follow-up of Alzheimer's disease. Owing to that, dogs are quite unique to investigate the early events taking place in the diffuse Abeta plaque maturation and its relationship with cognitive deficit. The(More)
The inflammatory central nervous system response that involves activated microglia and reactive astrocytes may both heal and harm neurons, as inflammatory mediators lead to neuroprotection or excitation at one dose but to injury at a different concentration. To investigate these complex cellular interactions, L-trans-pyrrolidine-2,4-dicarboxylate (PDC), a(More)
Diagnosis of dementia of the Alzheimer's type depends on clinical criteria and exclusion of other disorders because, at this time, a validated biological marker, aside from histological brain examination, remains to be established. The canine counterpart of senile dementia of the Alzheimer type (ccSDAT) is considered a promising model for examining(More)