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Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruitflies; however, whether inhibition of mTOR signalling can extend lifespan in a mammalian species was unknown. Here we report that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal(More)
BACKGROUND A decline in muscle mass and muscle strength characterizes normal aging. As clinical and animal studies show a relationship between higher cytokine levels and low muscle mass, the aim of this study was to investigate whether markers of inflammation are associated with muscle mass and strength in well-functioning elderly persons. METHODS We used(More)
OBJECTIVE The Arthritis, Diet, and Activity Promotion Trial (ADAPT) was a randomized, single-blind clinical trial lasting 18 months that was designed to determine whether long-term exercise and dietary weight loss are more effective, either separately or in combination, than usual care in improving physical function, pain, and mobility in older overweight(More)
BACKGROUND The serum concentration of interleukin 6 (IL-6), a cytokine that plays a central role in inflammation, increases with age. Because inflammation is a component of many age-associated chronic diseases, which often cause disability, high circulating levels of IL-6 may contribute to functional decline in old age. We tested the hypothesis that high(More)
Patients with major depression have elevated levels of inflammatory cytokines. We examined the link between inflammatory markers and depressed mood in a community-based sample of older people. Data are from 3024 well-functioning older persons, 70-79 years of age, participating in the Health, Aging and Body Composition study. Depressed mood was defined as a(More)
OBJECTIVES To determine how three different physical performance measures (PPMs) combine for added utility in predicting adverse health events in elders. DESIGN Prospective cohort study. SETTING Health, Aging and Body Composition Study. PARTICIPANTS Three thousand twenty-four well-functioning older persons (mean age 73.6). MEASUREMENTS Timed gait,(More)
BACKGROUND Some studies have proposed chronic inflammation as an underlying biological mechanism responsible for physical function decline in elderly people. The aim of this study is to evaluate the relationship between several inflammatory markers and physical performance in an older population. METHODS This study is part of the "Invecchiare in Chianti"(More)
BACKGROUND Inflammation plays an important role in cardiovascular disease. The aim of this study is to investigate the predictive value of several inflammatory markers on the incidence of cardiovascular events in well-functioning older persons. METHODS AND RESULTS The subjects were 2225 participants 70 to 79 years old, without baseline cardiovascular(More)
OBJECTIVES To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons. DESIGN Prospective cohort study. SETTING Health, Aging and Body Composition Study. PARTICIPANTS Three thousand forty-seven well-functioning older persons (mean age 74.2). MEASUREMENTS Usual(More)
OBJECTIVE To study the incidence and the risk factors of adverse drug reactions. DESIGN Multicenter survey. SETTING Hospitalized care: 22 internal medicine and 19 geriatric wards. PATIENTS All patients (n = 9,148) consecutively admitted during two observation periods of 2 months. MAIN OUTCOME MEASURE Incidence of adverse drug reactions. RESULTS(More)