Marco Michi

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A sensitive, selective and quantitative method for the simultaneous determination of casopitant, a potent and selective antagonist of the human Neurokinin 1 (NK-1) receptor, and its three major metabolites M12, M13 and M31 was developed and validated in dog and rat plasma. Acetonitrile containing stable labeled internal standards for the four analytes was(More)
BACKGROUND One of the main reasons for the increased popularity of dried blood spots (DBS) is related to the 3Rs principles (replacement, refinement and reduction) for animal use in drug development. The small blood volume collected using this technique may have a significant impact on the assay sensitivity. An approach that made use of hydrophilic(More)
2017 The world of bioanalysis is changing rapidly. The move toward the measurement of endogenous molecules to understand drug pharmacodynamics (PD), efficacy and toxicity and the expanding numbers of novel molecular constructs for pharmaceuticals (peptides, proteins, oligonucleotides, antibody–drug conjugates, gene therapy, etc.) bring exciting analytical(More)
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