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BACKGROUND In heart failure (HF), a defective nitric oxide signaling is involved in left ventricular (LV) diastolic abnormalities and remodeling. PDE5 inhibition, by blocking degradation of nitric(More)
AIMS Exercise oscillatory breathing (EOB) is a ventilatory abnormality that occurs in ∼20% of heart failure (HF) patients and carries a very unfavourable prognosis. Pulmonary vasoconstriction has(More)
Altitude hypoxia is a major challenge to the blood O2 transport system, and adjustments of the blood–O2 affinity might contribute significantly to hypoxia adaptation. In principle, lowering the(More)