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The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes.
TLDR
The ability of YAP to activate mitotic gene expression is dependent on the Myb-MuvB (MMB) complex, a master regulator of genes expressed in the G2/M phase of the cell cycle and is associated with poor survival of cancer patients. Expand
Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development
TLDR
It is demonstrated that mice lacking GAS2L3, a cytoskeleton-associated protein that interacts with actin filaments and tubulin, develop cardiomyopathy and heart failure after birth and that mice deficient in GAS 2L3 die shortly after birth because of heart failure. Expand
Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes
TLDR
It is shown that YAP directly binds to B-MYB, a transcription factor of the Myb-MuvB complex, and that proliferation of postnatal cardiomyocytes induced by constitutive active YAP depends on MMB. Expand
GAS2L3: Coordinator of cardiomyocyte cytokinesis?
TLDR
This work presents a new probabilistic procedure that allows for direct comparison of the response of the immune system to EMTs to treat central giant cell granuloma. Expand
Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes
TLDR
It is shown that the increased proliferation of embryonal and postnatal cardiomyocytes due to loss of the Hippo-signaling component SAV1 depends on the Myb-MuvB (MMB) complex, and YAP binds directly to B-MYB, a subunit of MMB, in a manner dependent on the YAP WW domains and a PPXY motif in B-MB. Expand
IQGAP3, a YAP target, is required for proper cell cycle progression and genome stability.
TLDR
The data indicate that, while IQGAP3 inhibition might be initially effective in decreasing cancer cell proliferation, this approach harbors the risk to promote aneuploidy and, therefore, the formation of more aggressive cancers. Expand