Marco Goicochea

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Recently, we and others have characterized the HIV-sup-pressive activity of human β-defensins (hBD) 1–3. Our mechanistic studies indicate that hBD2 inhibits HIV through two distinct mechanisms. The first mechanism results in lower HIV infectivity. The second mechanism is intracellular, since it is observed even delaying treatment up to 2 hours after(More)
Lassa hemorrhagic fever (LHF) is a rodent-borne viral disease that can be fatal for human beings. In this study, an attenuated Lassa vaccine candidate, ML29, was tested in SIV-infected rhesus macaques for its ability to elicit immune responses without instigating signs pathognomonic for arenavirus disease. ML29 is a reassortant between Lassa and Mopeia(More)
HTLV-1, the first tumorigenic retrovirus identified in humans, causes adult-T cell leukemia in about 5% of the infected individuals with a long latency period > 40 years. The mechanism of ATL has been extensively studied with emphasis on the role of regulatory factors encoded by the viral genome including Tax, Rex, p30 p12, p8 and p13. However, the recent(More)
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