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BACKGROUND We evaluated the contribution of ultrasound (US) in detecting breast cancer in women with dense breasts and negative mammograms. METHODS 9157 (35.8%) of 25,572 self-referring women during 2000-2007 had BI-RADS D3-4 negative mammograms - all were screened with bilateral US. RESULTS US detected 37 cancers - incremental cancer detection rate(More)
This paper deals with a Hub Location Problem arising in Telecom-munication Network Design. The considered network presents two different kinds of nodes: access nodes, that represent source and destination of traffic demands but cannot be directly connected, and transit nodes, that have no own traffic demand but collect traffic from access nodes and route it(More)
Surveillance of interval cancers (IC) provides a measure of breast screening efficacy. Increased breast density is a predictor of breast cancer risk and of the risk of IC in screening. Improving screening sensitivity in women with dense breasts, through adjunct ultrasound (US), may potentially reduce IC; however this has not been proven. We report on(More)
Although the phylogeography of European mammals has been extensively investigated since the 1990s, many studies were limited in terms of sampling distribution, the number of molecular markers used and the analytical techniques employed, frequently leading to incomplete postglacial recolonisation scenarios. The broad-scale genetic structure of the European(More)
In this paper, the problem of optimizing the performances of a distributed supply chain is faced by means of as decentralized architecture. In particular, a general scheme for an Lagrangian algorithm, based on Lagrangian relaxation of the precedence constraints, is presented. In this framework, the trade-off between the production cost of each node of the(More)