Marco Fossati

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We present the first attempt to perform full FrameNet annotation with crowdsourcing techniques. We compare two approaches: the first one is the standard annotation methodology of lexical units and frame elements in two steps, while the second is a novel approach aimed at acquiring frames in a bottom-up fashion, starting from frame element annotation. We(More)
In the digital era, Wikipedia represents a comprehensive cross-domain source of knowledge with millions of contributors. The DBpedia project transforms Wikipedia content into RDF and currently plays a crucial role in the Web of Data as a central multilingual interlinking hub. However, its main classification system depends on human curation, which causes it(More)
The monoclonal antibody rituximab has been increasingly used in the treatment of autoimmune diseases. By binding the CD20 antigen, rituximab induces a sustained depletion of circulating B lymphocytes [1]. In patients with idiopathic thrombocytopenic purpura and lupus nephritis, response to rituximab was found to be associated with expansion of CD4(More)
Interleukin-2 (IL-2) is a mainstay for current immunotherapeutic protocols but its usefulness in patients is reduced by severe toxicities and because IL-2 facilitates regulatory T (Treg) cell development. IL-21 is a type I cytokine acting as a potent T-cell co-mitogen but less efficient than IL-2 in sustaining T-cell proliferation. Using various in vitro(More)
Information overload on the Internet motivates the need for filtering tools. Recommender systems play a significant role in such a scenario, as they provide automatically generated suggestions. In this paper, we propose a novel recommendation approach, based on semantic networks exploration. Given a set of celebrity gossip news articles, our systems(More)
To determine whether abagovomab induces protective immune responses in ovarian cancer patients in first clinical remission. The present analysis is a substudy of monoclonal antibody immunotherapy for malignancies of the ovary by subcutaneous abagovomab trial (NCT00418574). The study included 129 patients, 91 in the abagovomab arm and 38 in the placebo arm.(More)
OBJECTIVE To explore the effects of intraperitoneal (i.p.) infusion of catumaxomab, a bispecific monoclonal antibody (anti-EpCAM×anti-CD3), on T cells, NK cells and macrophages in ascites of cancer patients and to understand how ascitic immune cells can be activated despite the pervasive immunosuppressive ability of ascites microenvironment. METHODS Six(More)
Synthetic oligodeoxynucleotides containing CpG motifs (CpG ODN) have been reported to induce antimycobacterial activity both in vitro and in vivo. The present study analyzes the signals leading to CpG ODN-induced antimicrobial activity in monocytes. In this context, CpG, but not GpC, ODN induced cytosolic Ca2+ influx of extracellular origin which, in turn,(More)
BACKGROUND The possible occurrence of an erroneous immunophenotyping due to interference between monoclonal antibodies (MoAbs) is often overlooked when the epitopes are assumed to be not close to each other. This is particularly important when exploring immune cell populations whose identification is still investigational. The commonly held view is that(More)