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Application of Human Type I Pancreatic Elastase (PRT-201) to the venous Anastomosis of Arteriovenous Grafts in Patients with Chronic Kidney Disease
Purpose To explore the safety and efficacy of PRT-201 applied to the outflow vein of a newly created arteriovenous graft (AVG). Methods Randomized, double-blind, placebo-controlled, single-doseExpand
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The ability of serum from alpha 1‐antitrypsin–deficient patients to inhibit PRT‐201, a recombinant human type I pancreatic elastase
PRT‐201 is a recombinant human pancreatic elastase under development as a treatment for blood vessels to promote hemodialysis access patency. Proteases such as elastase are normally inactivated byExpand
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Recombinant Human Elastase Alters the Compliance of Atherosclerotic Tibial Arteries After Ex Vivo Angioplasty
Purpose: This study was designed to determine whether vonapanitase (formerly PRT-201), a recombinant human elastase, treatment can fragment the protein elastin in elastic fibers and cause dilation ofExpand
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Effects of Recombinant Human Type I Pancreatic Elastase on Human Atherosclerotic Arteries
Rationale: At physiologic pressures, elastic fibers constrain artery diameter. Local treatment of atherosclerotic arteries with PRT-201, a recombinant type I elastase, could result in fragmentationExpand
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Studies of human pancreatic elastase treatment of rabbit and human vein rings to predict human therapeutic doses
Vascular tissue contains abundant elastic fibers that contribute to vessel elasticity. Vonapanitase (formerly PRT‐201) is a recombinant human chymotrypsin‐like elastase family member 1 (CELA1) shownExpand
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Recombinant Human Elastase Treatment of Cephalic Veins.
BACKGROUND Vessel injury at the time of Arteriovenous Fistula (AVF) creation may lead to neointimal hyperplasia that impairs AVF maturation. Vonapanitase, a recombinant human chymotrypsin-likeExpand
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PATENCY-2 trial of vonapanitase to promote radiocephalic fistula use for hemodialysis and secondary patency.
OBJECTIVE Arteriovenous fistulas created for hemodialysis often fail to become usable and are frequently abandoned. This prospective trial evaluated the efficacy of vonapanitase, a recombinant humanExpand
TCT-159 Effects of PRT-201, a Recombinant Human Type I Pancreatic Elastase, Treatment on the Elastin Content and Compliance of Atherosclerotic Tibial Arteries Following Ex Vivo Angioplasty
At physiologic pressures, the elastin fiber network constrains artery diameter. Fragmenting elastin fibers following successful angioplasty of atherosclerotic arteries could result in larger arteryExpand