Marco Castellaro

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In this study, dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) was used to quantify the cerebral blood flow (CBF), the cerebral blood volume (CBV), and the mean transit time (MTT) and to analyze the changes in cerebral perfusion associated with the cortical lesions in 44 patients with relapsing-remitting multiple sclerosis. The cortical(More)
BACKGROUND Both gray-matter (GM) atrophy and lesions occur from the earliest stages of Multiple Sclerosis (MS) and are one of the major determinants of long-term clinical outcomes. Nevertheless, the relationship between focal and diffuse GM damage has not been clarified yet. Here we investigate the regional distribution and temporal evolution of cortical(More)
PURPOSE QUASAR arterial spin labeling (ASL) permits the application of deconvolution approaches for the absolute quantification of cerebral perfusion. Currently, oscillation index regularized singular value decomposition (oSVD) combined with edge-detection (ED) is the most commonly used method. Its major drawbacks are nonphysiological oscillations in the(More)
In order to assess brain perfusion, one of the available methods is the estimation of parameters such as cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) from Dynamic Susceptibility Contrast MRI (DSC-MRI). This estimation requires both high temporal and spatial resolution to capture the rapid tracer kinetic and detect small(More)
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