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- Carmelo Quarta, Luigi Bellocchio, +27 authors Uberto Pagotto
- Cell metabolism
- 2010
The endocannabinoid system (ECS) plays a critical role in obesity development. The pharmacological blockade of cannabinoid receptor type 1 (CB(1)) has been shown to reduce body weight and to… (More)
- Patricia Iozzo, Riikka Lautamaki, +9 authors P. Nuutila
- The Journal of clinical endocrinology and…
- 2009
CONTEXT AND OBJECTIVE
To examine whether pericardial and myocardial fat depots may contribute to the association between diabetes and cardiovascular risk, including sex-related differences, and the… (More)
- Marco Bucci, Esa Joutsiniemi, +11 authors Patricia Iozzo
- Arteriosclerosis, thrombosis, and vascular…
- 2011
OBJECTIVE
To measure intrapericardial fat (IPF), extrapericardial fat (EPF), and myocardial perfusion (MBF) in patients with and without coronary artery disease (CAD), hypothesizing that perfusion is… (More)
- Patricia Iozzo, Marco Bucci, +13 authors P. Nuutila
- Gastroenterology
- 2010
BACKGROUND & AIMS
Hepatic lipotoxicity results from and contributes to obesity-related disorders. It is a challenge to study human metabolism of fatty acids (FAs) in the liver. We combined… (More)
- Francesco Cipollone, Claudio Ferri, +11 authors Andrea Mezzetti
- Circulation
- 2003
BACKGROUND
Inflammation plays a pathogenic role in the development of restenosis after percutaneous transluminal coronary angioplasty (PTCA). CD40-CD40L interaction is involved in the pathogenesis of… (More)
- Donato Santovito, Velia de Nardis, +8 authors Francesco Cipollone
- The Journal of clinical endocrinology and…
- 2014
CONTEXT
Type 2 diabetes is a chronic disease characterized by inadequate β-cell response to the progressive insulin resistance. MicroRNAs (miRNAs) are short, endogenous, noncoding RNAs representing a… (More)
- Jussi Hirvonen, Kirsi A. Virtanen, +8 authors Pirjo Nuutila
- Diabetes
- 2011
OBJECTIVE
Insulin stimulates brain glucose metabolism, but this effect of insulin is already maximal at fasting concentrations in healthy subjects. It is not known whether insulin is able to… (More)
- Francesco Cipollone, Maria Luigia Fazia, +12 authors Andrea Mezzetti
- Circulation
- 2004
BACKGROUND
Clinical trials have demonstrated that agents that inhibit the angiotensin II pathway confer benefit beyond the reduction of blood pressure alone. However, the molecular mechanism… (More)
- Carla Cicala, André Bósio Pinto, +7 authors Giuseppe Cirino
- Circulation
- 1999
BACKGROUND
The protease-activated receptor-2 (PAR-2) is expressed by vascular endothelial cells and upregulated by lipopolysaccharide (LPS) in vitro. PAR-2 is activated by a tethered ligand created… (More)
- Francesco Cipollone, Andrea Mezzetti, +8 authors Diana M. Stafforini
- Arteriosclerosis, thrombosis, and vascular…
- 2005
OBJECTIVE
The participation of 5-lipoxygenase (5-LO) in the development of atherosclerosis has been suggested by recent studies. However, a role for 5-LO as a modulator of atherosclerotic plaque… (More)