Marco Bigelli

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Schizophrenia is associated with a high familiar, social and economic burden. During the recent years early and specific intervention for first psychotic episodes has been suggested to improve the long term outcome of the disease. Despite the promising results obtained so far, early intervention is still scarcely applied. One major problem arises from the(More)
OBJECTIVE To evaluate the benefit of pharmacogenetics in antidepressant treatment. METHODS In a simulated trial 100,000 subjects in a current episode of major depressive disorder (MDD) received citalopram or bupropion based on the clinician's decision (algorithm A) or following indications from 5-HTTLPR genetic testing (algorithm B), which effect size of(More)
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may(More)
The serotonin transporter 5-HTTLPR polymorphism moderates response to SSRIs and side-effect burden. The aim of this study is to quantify the cost-utility of incorporating 5-HTTLPR genotyping in drug treatment of major depressive disorder (MDD). We previously reported a theoretical model to simulate antidepressant treatment with citalopram or bupropion for(More)
A.) and seminar participants at Tilburg University for providing many helpful comments. The usual disclaimer applies. Abstract In this study we investigate the role of leverage in disciplining overinvestment problems. We measure the relationships between leverage, Tobin's q and corporate governance characteristics for Dutch listed firms. Besides, our(More)
  • Clifford G Holderness, Vladimir Atanasov, David Chapman, Alex Edmans, Rainer Gawlick, Stuart Gillan +65 others
  • 2016
Shareholder approval of equity issuances varies considerably. When shareholders must approve issuances, average announcement returns are positive. When managers unilaterally issue stock, returns are 4% lower and negative. The closer the vote is to the issuance or the greater is the required plurality, the higher are the returns for public offers, rights(More)
In major depression, when a first antidepressant does not cause remission of symptoms (60%-75%), there are several options for continuing treatment in the next step. This study is a cost-utility analysis (CUA) of different second-line approaches. In a simulated trial outpatients with MDD were treated with citalopram for 13 weeks (level 1), then based on two(More)
Though the value of a right should be not lower than zero, negative voting premiums often appear in recent empirical evidence. The present paper highlights some possible measurement errors and contemporary proposes a new measure, the vote segment, which incorporates all dividend privileges. Results from Italian non-voting shares listed in the 1999-2008(More)
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