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The recommendations set forth in this report are those of the Task Force Members and do not necessarily reflect the official position of the American College of Cardiology. *Co-chairpersons. †Dr Shanti Mendis of the World Health Organization participated in the task force in her personal capacity, but this does not represent WHO approval of this document at(More)
Recent studies provide evidence on the emerging role of the SOCS1 gene in the development and progression of atherosclerotic lesions. This gene encodes for the suppressor of the cytokine signaling-1 protein that interacts directly with the Janus kinases that are essential intracellular mediators of the immune cytokine action. The aim of this study was to(More)
Inflammation plays an essential role in the development and progression of atherosclerotic lesions. Cytokines of the interleukin-1 family are central regulators in immunoinflammatory mechanisms. In the present work, the role of interleukin 1 (IL-1) and IL-1 receptor antagonist (IL-1RN) gene polymorphisms as susceptibility markers for acute coronary syndrome(More)
There is continued debate as to whether a combined reperfusion regimen with platelet glycoprotein IIb/IIIa inhibitors provides additional benefit in optimal myocardial reperfusion of patients with a ST-elevation acute myocardial infarction (AMI). In addition, the best angiographic method to evaluate optimal myocardial reperfusion is still controversial.(More)
A three-year prospective study was conducted to assess the efficacy and safety of transjugular liver biopsy with a Trucut-type needle employing an automated device. Fifty-two consecutive patients (39 women and 13 men), ages 46.3+/-14.6 years, in whom percutaneous liver biopsy was contraindicated were included in the study. An 18-gauge transjugular hepatic(More)
tensin, vasopressin and methoxamine on cardiac function and blood flow distribution in conscious dogs. SUMMARY We followed 110 children, ages 6-15 years, who had undergone mitral valve replacement for rheumatic heart disease. Group 1 consisted of 74 patients with mechanical prostheses and a mean follow-up of 6.3 years. Group 2 consisted of 13 patients with(More)
BACKGROUND inflammation plays an essential role in the development and progression of atherosclerotic lesions and plaque disruption. Cytokines are central regulators in immunoinflammatory mechanisms. The aim of the present study was to evaluate the role of INF-γ and IL-6 gene polymorphisms as susceptibility markers for acute coronary syndromes (ACS) in a(More)
BACKGROUND Inflammation plays an essential role in the development and progression of atherosclerotic lesions. The major histocompatibility complex class II trans-activator (MHC2TA) is considered an important molecule in the inflammatory process regulation. The aim of the present study was to evaluate the role of MHC2TA gene polymorphisms as susceptibility(More)
BACKGROUND Clopidogrel is a pro-drug and its intestinal absorption is limited by the P-glycoprotein encoded by the ABCB1 gene. It is metabolized hepatically by cytochrome P450 enzymes encoded by CYP genes to produce an active metabolite that antagonizes the P2Y12 platelet receptor. Some patients exhibit poor clopidogrel responsiveness due to polymorphisms,(More)