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BACKGROUND Leprosy is a chronic infectious disease that affects 250,000 new individuals/year worldwide. Genetic analysis has been successfully applied to the identification of host genetic factors affecting susceptibility to leprosy; however, a consensus regarding its mode of inheritance is yet to be achieved. METHODS We conducted a complex segregation… (More)
Gradual depletion of oxygen causes the shift-down of aerobic growing Mycobacterium bovis BCG to an anaerobic synchronized state of nonreplicating persistence. The persistent culture shows induction of glycine dehydrogenase and alpha-crystallin-like protein and is sensitive to metronidazole.
Strains were constructed that contain mutational alterations affecting two distinct functional domains within the araC gene protein. The araCi (catabolite repression insensitivity) and araCh (catabolite repression hypersensitivity) mutations were used to alter the catabolite repression sensitivity domain, and mutation to D-fucose resistance was used to… (More)
This paper describes AMANDA 2 , a framework for mediating collective discussions in distance learning environments. The objective of this framework is to help tutors achieve better results from group discussions and improve knowledge transfer among the participants. The overall idea is to organize the group discussion as an argumentation tree and involve… (More)
Seven l-arabinose-negative mutations are described that map in three genetically distinct regions immediately adjacent to the araO (operator) region of the l-arabinose operon. All seven mutants revert spontaneously, exhibit a cis-dominant, trans-recessive polarity effect upon the expression of l-arabinose isomerase (gene araA), and fail to respond to amber,… (More)
This paper discusses the role of ontology for an intelligent agent designed for coordinating domain dialogs among participants of a distance learning environment. The domain models used by the agent are centered on the ontological representation of the domain concepts. The agent's behavior as well as the adequacy of the domain models have been tested in… (More)
Mutations causing hypersensitivity to catabolite repression have been assigned to gene araC (activator protein) by complementation analysis. The araO (operator region) is non-essential for catabolite repression.