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The increasing exposure of human populations to excessive levels of metals continues to represent a matter of public health concern. Several biomarkers have been studied and proposed for the detection of adverse health effects induced by lead (Pb), arsenic (As), and manganese (Mn); however, these studies have relied on exposures to each single metal, which(More)
Lead (Pb), arsenic (As) and manganese (Mn) are neurotoxic elements that often occur in mixtures for which practically no information is available on biomarkers (BMs) for the evaluation of exposure/effects. Exposures to these metals may increase delta-aminolevulinic acid (delta-ALA), which in itself may potentiate neurotoxicity. The objective of this study(More)
Risk prevention of human exposure against n-hexane neurotoxicity is relevant towards the protective measures to be proposed in occupational toxicology. Metabolic studies have identified 2,5-hexanedione (2,5-HD) as the main neurotoxic metabolite of n-hexane, which reacts with amino groups of lysine in axonal neurofilaments forming 2,5-dimethylpyrrole(More)
The neurotoxic metals lead (Pb), arsenic (As) and manganese (Mn) are ubiquitous contaminants occurring as mixtures in environmental settings. The three metals may interfere with enzymes of the heme bioshyntetic pathway, leading to excessive porphyrin accumulation, which per se may trigger neurotoxicity. Given the multi-mechanisms associated with metal(More)
The Internet-of-Things is a dynamic global network infrastructure where physical and virtual things communicate and share information amongst themselves. Plug-and-Interoperate is an approach that allows heterogeneous things to plug (into data) and seamlessly exchange information within the environment. To allow that, Plug-and-Interoperate needs to have the(More)
Internet-of-Things (IoT) is characterized by the heterogeneity of the used devices, which leads to information exchange problems. To address these problems, the Plug'n'Interoperate approach is used, where the steps needed to perform the information exchange between devices are described by interoperability specifications (IS) and are operated by the(More)
Managing interoperability in heterogeneous environments is of major importance for supporting collaboration between systems. Interoperability today is defined through the use of a Model Driven approach, which is able to represent information models and their transformations of constituent systems. Therefore, a solution for managing Model Driven(More)
Lead (Pb) continues to be a major toxic metal in the environment. Pb exposure frequently occurs in the presence of other metals, such as arsenic (As) and manganese (Mn). Continued exposure to low levels of these metals may lead to long-term toxic effects due to their accumulation in several organs. Despite the recognition that metals in a mixture may alter(More)
Interoperability is a key aspect of collaborative systems especially in massive and highly distributed environments such as the Internet of Things. Know how systems can communicate among themselves in order to lose as little information as possible is a key challenge. To meet this challenge one needs to set methods to measure the Interoperability Capacity(More)
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