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Validation of a Plasma-Based Comprehensive Cancer Genotyping Assay Utilizing Orthogonal Tissue- and Plasma-Based Methodologies
High concordance with orthogonal clinical plasma- and tissue-based genotyping methods supports the clinical accuracy of digital sequencing across all four types of targetable genomic alterations. Expand
Validation of Microsatellite Instability Detection Using a Comprehensive Plasma-Based Genotyping Panel
Purpose: To analytically and clinically validate microsatellite instability (MSI) detection using cell-free DNA (cfDNA) sequencing. Experimental Design: Pan-cancer MSI detection using Guardant360 wasExpand
Molecular phylogeny of Miltogramminae (Diptera: Sarcophagidae): Implications for classification, systematics and evolution of larval feeding strategies.
Ancestral state reconstruction of larval feeding strategy and five larval characters reveals that the ancestor of Miltogramminae was likely a saprophage retaining plesiomorphic oral ridges and a cephaloskeleton with sclerotized dorsal bridge, suggesting that the ancestral first instar larva actively searched for a buried food supply. Expand
Correlations between polymorphisms in genes coding elements of dopaminergic pathways and body mass index in overweight and obese women.
The effect on body mass of these two polymorphisms may combine and cause hypo-functionality of the dopaminergic reward system when the two analysed polymorphisms were combined, the spread between the mean BMI values became greater than for single genes. Expand
Cytoprophet: a Cytoscape plug-in for protein and domain interaction networks inference
Cytoprophet implements three algorithms that predict new potential physical interactions using the domain composition of proteins and experimental assays to take advantage of the visual capabilities of Cytoscape and be simple to use. Expand
Association between COMT Val158Met and DAT1 polymorphisms and depressive symptoms in the obese population
Polymorphisms in the DAT1 and COMT genes are associated with a greater intensity of depressive symptoms in the obese population, as well as severity of obesity. Expand
Single Nucleotide Polymorphism Discovery in Bovine Pituitary Gland Using RNA-Seq Technology
A breed-specific model is reported to successfully perform the detection of SNPs in the pituitary gland of young growing bulls representing Polish Holstein-Friesian, Polish Red, and Hereford breeds at three developmental ages viz., six months, nine months, and twelve months. Expand
Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Contex of Executive Functions and Working Memory in Obese Patients
According to results, BDNF Val66Met polymorphism seems to contribute to greater obesity in this study, and it is greater BMI, rather than genotype, which caused worse executive functioning and working memory. Expand
Abstract 5603: Analytical validation of a comprehensive 500-gene ctDNA panel designed for immuno-oncology and DNA damage research
The first analytical validation study of GuardantOMNI, a highly sensitive 500-gene cfDNA sequencing test requiring as little as 2 mL of plasma and designed for broad genomic detection of somatic single-nucleotide variants and small indels, is presented. Expand