Marcin J. Kurowski

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In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a(More)
This document is the result of a consensus on the mechanisms of exercise-induced anaphylaxis (EIAn), an unpredictable and potentially fatal syndrome. A multidisciplinary panel of experts including exercise physiologists, allergists, lung physicians, paediatricians and a biostatistician reached the given consensus. Exercise-induced anaphylaxis (EIAn)(More)
INTRODUCTION Polymorphisms within innate immunity genes are associated with allergic phenotypes but results are variable. These associations were not analyzed with respect to allergen exposure. We investigated associations of TLR and CD14 polymorphisms with allergy phenotypes in the context of house dust mite (HDM) exposure. MATERIAL AND METHODS Children,(More)
PURPOSE Periostin is considered a biomarker for eosinophilic airway inflammation and have been associated with NSAID-Exacerbated Respiratory Disease (NERD) and chronic rhinosinusitis (CRS). In this study, we aimed to evaluate periostin in exhaled breath condensate (EBC) and in serum of patients with various asthma phenotypes. METHODS The study included 40(More)
  • J. J. van der Dussen, S. R. de Roode, +5 authors A. P. Siebesma
  • 2012
Large eddy simulation (LES) results of a transition from a rel-4 atively well-mixed to a thin, decoupled stratocumulus layer with cumulus 5 cloud penetration from below, are compared to aircraft observations collected 6 during the Atlantic Stratocumulus Transition Experiment (ASTEX). Despite 7 the complexity of the case and the long simulation period of 40(More)
The vast fields of subtropical marine stratocumulus off the western coasts of continents are known for their persistent existence. In these regions, the large-scale subsidence associated with Hadley circulation provides favorable conditions for the formation of strong inversion, which separates moist and cool stratocumulustopped boundary layer (STBL) from(More)
BACKGROUND Respiratory epithelium integrity impairment caused by intensive exercise may lead to exercise-induced bronchoconstriction. Clara cell protein (CC16) has anti-inflammatory properties and its serum level reflects changes in epithelium integrity and airway inflammation. This study aimed to investigate serum CC16 in elite athletes and to seek(More)
BACKGROUND Cyclooxygenase-1 (COX-1) is a key enzyme involved in generation of prostanoids, important mediators and modulators of asthmatic inflammation. In a subpopulation of aspirin-sensitive asthmatics (ASA) inhibition of COX-1 by nonsteroidal anti-inflammatory drugs results in activation of inflammatory cells and development of symptoms. Alternatively(More)