Marcia L. Hardy

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Decabromodiphenyl oxide (DBDPO) is a highly effective flame retardant that is primarily used in electrical and electronic equipment with a secondary, but important, application in upholstery textiles. DBDPO, the second largest volume brominated flame retardant in use today, has undergone a wide range of toxicology tests in mammalian species with the results(More)
Three commercial polybrominated diphenyl oxide flame retardants (PBDPO, PBDE) are manufactured: decabromodiphenyl oxide (DBDPO), octabromodiphenyl oxide (OBDPO) and pentabromodiphenyl oxide (PeBDPO). The composition, production volumes, uses and toxicology of the three products differ. In 1999, DBDPO accounted for approximately 82% of the global PBDPO(More)
BACKGROUND The potential embryotoxic and teratogenic effects of decabromodiphenyl ethane (DBDPEthane; CASRN 84852-53-9) were evaluated in prenatal developmental studies using rats and rabbits and performed in accordance with international guidelines and Good Laboratory Practice standards. Preliminary dose-range-finding studies were conducted, which(More)
BACKGROUND Decabromodiphenyl ether (DecaBDE; CASRN 1163-19-5) is a flame retardant used in a variety of manufactured products. A single oral dose of 20.1 mg/kg administered to mice on postnatal day 3 has been reported to alter motor activity at 2, 4, and 6 months of age. METHODS To further evaluate these results, a developmental neurotoxicity study was(More)
Van der Ven et al. (2008) report results from two studies perormed in Wistar rats with tetrabromobisphenol A (TBBPA)—a 8-day repeated dose study at doses of 0, 30, 100, and 300mg/kg of ody weight/day (mg/kg-day) and a dietary one-generation reprouction assay at 0, 3, 10, 30, 100, 300, 1000, and 3000mg/kg-day. he authors concluded themost sensitive endpoints(More)
Fischer et al. (2008) report an interaction between 2,2′,4,4′,5,5′hexachlorobiphenyl (PCB 153) and methyl mercury at enhancing developmental neurotoxic effects (i.e., disrupted spontaneous behavior, lack of habituation, and reduced cognitive function) in neonatal mice. The authors state the following about their experimental design: “[w]e have established(More)
Ethane, 1,2-bis(pentabromophenyl) (EBP; CAS no. 8452-53-9) dose levels of 0, 100, 320 and 1000 mg/kg/day administered to rats by gavage in corn oil for 90 consecutive days produced no compound-related clinical signs of systemic toxicity, ocular lesions, or alterations in urinalysis, clinical chemistry, and hematology values in the treated or recovery(More)