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The current state of serum biomarkers of hepatotoxicity.
Environmental toxins and Parkinson's disease.
The role of environmental and Occupational exposure to Chemicals in Parkinson’s Disease and the Nigrostriatal Pathway and PD is studied to determine the role of Oxidative Stress.
Combined administration of levetiracetam and valproic acid attenuates age‐related hyperactivity of CA3 place cells, reduces place field area, and increases spatial information content in aged rat…
- J. Robitsek, Marcia H Ratner, Tara M. Stewart, H. Eichenbaum, D. Farb
- Biology, PsychologyHippocampus
- 14 July 2015
It is demonstrated that spatial information content, or the number of bits of information encoded per action potential, may be the key correlate for enhancement of spatial memory by LEV + VPA.
Targeting the Modulation of Neural Circuitry for the Treatment of Anxiety Disorders
It is posited that a systems-level discovery platform combined with an individualized medicine approach based on noninvasive brain imaging would substantially advance the development of more effective therapeutics in human anxiety.
Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders
The effects of both endogenously active and exogenously administered neurosteroids on neural networks across the life span of women and men point to a possible underlying pharmacological connectome by which these neuromodulators might act to modulate memory across diverse altered states of mind.
Younger age at onset of sporadic Parkinson's disease among subjects occupationally exposed to metals and pesticides
- Marcia H Ratner, D. Farb, J. Ozer, R. Feldman, R. Durso
- PsychologyInterdisciplinary toxicology
- 1 September 2014
It is suggested that chronic exposure to metals and pesticides is associated with a younger age at onset of PD among patients with no family history of the disease and that duration of exposure is a factor in the magnitude of this effect.
Chronic toxic encephalopathy in a painter exposed to mixed solvents.
The patient and his family noticed impaired short-term memory function and changes in affect in his early forties, which progressed until after he stopped working and was thus no longer exposed to paints and solvents, which are consistent with chronic toxic encephalopathy.
Amyotrophic lateral sclerosis-A case report and mechanistic review of the association with toluene and other volatile organic compounds.
- Marcia H Ratner, J. Jabre, W. M. Ewing, M. Abou‐Donia, L. C. Oliver
- Psychology, BiologyAmerican journal of industrial medicine
- 1 March 2018
The hypothesis that exposure to VOCs such as toluene, which disrupt motor function and increase oxidative stress, can unmask latent ALS type neuromuscular disorder in susceptible individuals is put forth.
The pathogenesis of neurodegenerative disease: neurotoxic mechanisms of action and genetics.
A pragmatic approach to future research in the area of neurodegenerative disease is developed on the basis of the interrelationship between known routes of neurotoxicant metabolism and human genetics.
Understanding of the role of manganese in parkinsonism and Parkinson disease
Evidence for a dose-response relationship between ongoing exposure to this neurotoxic heavy metal—which also plays an important role in the function of the antioxidant enzyme superoxide dismutase—and progression of parkinsonian symptoms is provided.