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The current state of serum biomarkers of hepatotoxicity.
TLDR
An examination of the current state of hepatotoxic biomarkers indicates that serum F protein, arginase I, and glutathione-S-transferase alpha (GSTalpha) levels, all measured by ELISA, may show utility, however, antibody availability and high cost per run may present limitations to widespread applicability in preclinical safety studies. Expand
Combined administration of levetiracetam and valproic acid attenuates age‐related hyperactivity of CA3 place cells, reduces place field area, and increases spatial information content in aged rat
TLDR
It is demonstrated that spatial information content, or the number of bits of information encoded per action potential, may be the key correlate for enhancement of spatial memory by LEV + VPA. Expand
Targeting the Modulation of Neural Circuitry for the Treatment of Anxiety Disorders
TLDR
It is posited that a systems-level discovery platform combined with an individualized medicine approach based on noninvasive brain imaging would substantially advance the development of more effective therapeutics in human anxiety. Expand
Younger age at onset of sporadic Parkinson's disease among subjects occupationally exposed to metals and pesticides
TLDR
It is suggested that chronic exposure to metals and pesticides is associated with a younger age at onset of PD among patients with no family history of the disease and that duration of exposure is a factor in the magnitude of this effect. Expand
Chronic toxic encephalopathy in a painter exposed to mixed solvents.
TLDR
The patient and his family noticed impaired short-term memory function and changes in affect in his early forties, which progressed until after he stopped working and was thus no longer exposed to paints and solvents, which are consistent with chronic toxic encephalopathy. Expand
Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders
TLDR
The effects of both endogenously active and exogenously administered neurosteroids on neural networks across the life span of women and men point to a possible underlying pharmacological connectome by which these neuromodulators might act to modulate memory across diverse altered states of mind. Expand
The pathogenesis of neurodegenerative disease: neurotoxic mechanisms of action and genetics.
TLDR
A pragmatic approach to future research in the area of neurodegenerative disease is developed on the basis of the interrelationship between known routes of neurotoxicant metabolism and human genetics. Expand
Understanding of the role of manganese in parkinsonism and Parkinson disease
TLDR
Evidence for a dose-response relationship between ongoing exposure to this neurotoxic heavy metal—which also plays an important role in the function of the antioxidant enzyme superoxide dismutase—and progression of parkinsonian symptoms is provided. Expand
Approach to neurotoxicity tort cases.
TLDR
The appropriate application and interpretation of conventional neurologic, neurophysiologic, neuropsychological, and biochemical diagnostic tests that are sensitive to neurotoxic exposures are defined. Expand
Neurological effects of chronic occupational exposure to alcohol mists and vapors in a machinist
TLDR
A 50-year-old machinist who intentionally used undiluted 200 proof ethanol as a cutting fluid while turning metal machine parts on a toolroom lathe for a period of 3 years began to experience central nervous system symptoms including headaches, fatigue, ataxia, and concentration and memory problems. Expand
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