Marcelo Rocha Sousa Cruz

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Meningeal carcinomatosis (MC) occurs in up to 5% of breast cancer patients. Few studies have evaluated prognostic markers in breast cancer patients with MC. Our aim was to describe the treatment of breast cancer patients with MC, and identify prognostic factors related to survival. Sixty breast cancer patients that had a diagnosis of MC between January 2003(More)
Paracoccidioides brasiliensis is a pathogenic fungus that undergoes a temperature-dependent cell morphology change from mycelium (22 degrees C) to yeast (36 degrees C). It is assumed that this morphological transition correlates with the infection of the human host. Our goal was to identify genes expressed in the mycelium (M) and yeast (Y) forms by EST(More)
Bevacizumab may improve outcomes of patients with breast cancer, but the absence of an established biomarker hampers patient selection and researchers´ ability to demonstrate a clear survival benefit. Its putative target, circulating VEGF-A, emerged as the main candidate and we sought to identify the relationship between VEGF-A levels and outcomes through(More)
BACKGROUND Peritoneal carcinomatosis is a common pattern of recurrence in gastric cancer and is associated with a poor prognosis. Determining predictive factors for peritoneal recurrence can help the selection of patients suitable for more aggressive treatment strategies. METHODS A retrospective chart review of 162 patients diagnosed with gastric cancer(More)
Malignant pineal tumors are rare entities in adult patients, comprising less than 1% of primary central nervous system neoplasms. Herein, we report a 51-years-old patient with pineoblastoma with clinical manifestation, follow up MRI, treatment receive and the response to chemotherapy treatment. Adjuvant chemotherapy with cisplatin, etoposide and(More)
e18067 Background: The combination of pemetrexed plus cisplatin (PC) was recently approved in the initial treatment of advanced stage non-small cell lung cancer (NSCLC). Studies reported comparable efficacy of the combination pemetrexed plus carboplatin (PCar) in the same setting. METHODS We assessed 69 patients with locally advanced or metastatic NSCLC(More)
Gastric cancer is the second leading cause of death due to cancer worldwide and is particularly prevalent in Brazil. Promising new therapeutic agents have already shown activity in some gastrointestinal malignancies and their role in gastric cancer will need to be evaluated. Determining the prognostic factors of survival for patients with gastric cancer can(More)
AIM Delay in commencing adjuvant therapy for colorectal cancer seems to impair survival in some retrospective studies. This study was planned to evaluate its impact on survival. METHODS This was a retrospective study enrolling patients registered from 2000 to 2012 in two large cancer-dedicated institutions in Brazil. The primary outcome was overall(More)
OBJECTIVE To investigate methods of fertility preservation in younger women exposed to adjuvant chemotherapy for breast cancer. DESIGN Systematic review of literature. SETTING Academic Department of Medical Oncology. PATIENT(S) Premenopausal women exposed to adjuvant chemotherapy for breast cancer. MAIN OUTCOME MEASURE(S) Fertility preservation. (More)