Marcelo Roberto Pereira Freitas

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BACKGROUND Glioblastoma (GBM) confers a dismal prognosis despite advances in current therapy. Cancer-testis antigens (CTA) comprise families of tumor-associated antigens that are immunogenic in different cancers. The aim of this study was to determine the expression profile of a large number of CTA genes in GBM. METHODS We selected, from 153 CTA genes,(More)
INTRODUCTION Cerebellar high-grade astrocytoma is uncommon. Although more prone to present cerebrospinal fluid dissemination, the cerebellar location is not particularly related to the occurrence of extra-cranial metastases, which are also unusual in supratentorial malignant gliomas. CASE REPORT A 46 year-old man with cerebellar anaplastic astrocytoma who(More)
Objective: To compare the prognosis estimated by standard prognostic criteria versus the prognosis estimated by the Oncotype DX. Methods: A retrospective study was performed on 22 patients with positive estrogen receptor, early-stage breast cancer who had an Oncotype DX recurrence score available. Results: Kappa value between Oncotype DX and standard(More)
OBJECTIVE To compare the prognosis estimated by standard prognostic criteria versus the prognosis estimated by the Oncotype DX. METHODS A retrospective study was performed on 22 patients with positive estrogen receptor, early-stage breast cancer who had an Oncotype DX recurrence score available. RESULTS Kappa value between Oncotype DX and standard(More)
e12518 Background: Glioblastoma (GBM) is a highly invasive and aggressive tumor which confers a dismal prognosis despite advances of current therapy. Cancer vaccines have been utilized as treatment of other tumors and might be an option for brain tumors. Cancer-testis (CT) genes represent promising targets for immunotherapeutic approaches as they are(More)
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