Marcelo Gomes da Silva Bruno

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To determine the role of surfactant protein-A (SP-A) in host defense, the murine SP-A locus was targeted by homologous recombination to produce mice lacking SP-A. SP-A-/- and wild-type mice were infected with mucoid Pseudomonas aeruginosa by intratracheal instillation. Pulmonary bacterial loads were greater in SP-A-/- than in wild-type mice, with increased(More)
– Registration of multiple sensors through common targets of opportunity is an extensively studied problem. The majority of proposed methods for computationally efficient estimation of sensor biases considered only the case of synchronous sensors. The relatively recent EXX method, however, allows exact estimation (under certain conditions) of sensor biases(More)
The C57BL/10 sps/sps mouse mutant displays generalized absence seizure-like behavior. In these mice, glutamic acid decarboxylase activity is reduced in the cortex and hippocampus. Tritiated flunitrazepam binding (3H-flu) is reduced in these areas, as well as in midbrain, cerebellum, and pons-medulla. Quantitative [3H]-flunitrazepam binding autoradiography(More)
There is evidence suggestive of the possible neuromodulatory role for L-proline in the mammalian brain. The binding of proline to whole mouse brain synaptic membranes has been partially characterized. Several binding sites for this imino acid have been identified; one in the nanomolar range and at least two in the submicromolar range. The binding of proline(More)
L-proline has been shown to exert a variety of physiological and behavioral effects that are consistent with its possible role as a neuromodulator in the mammalian brain. The binding of l-proline to mouse brain synaptosomes has been partially characterized. Preliminary kinetic analysis shows the presence of at least two binding sites in the submicromolar(More)
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